Evidence map›Paper›PMID 36810111›Full record

ArticlePediatric rheumatology online journal2023

Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening: analysis of the international Pharmachild registry.

Joeri W van Straalen, Laurie Baas, Gabriella Giancane, Lyudmila Grebenkina, Jurgen Brunner, Gabriel Vega-Cornejo, Vyacheslav G Chasnyk, Liora Harel, Simone Appenzeller, Elisabeth Gervais and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 7 countries.

Joeri W van StraalenDepartment of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. box 85090, 3508 AB, Utrecht, The Netherlands. j.w.vanstraalen-2@umcutrecht.nl.ORCID http://orcid.org/0000-0002-8766-6694
Laurie BaasDepartment of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. box 85090, 3508 AB, Utrecht, The Netherlands.
Gabriella GiancaneClinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Lyudmila GrebenkinaPediatric Department, Togliatti City Clinical Hospital №5, Togliatti, Russia.
Jurgen BrunnerPediatric Rheumatology, Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria.
Gabriel Vega-CornejoClínica Pediátrica de Reumatología y Enfermedades Autoinmunes (CREA), Hospital México Americano, Guadalajara, Mexico.
Vyacheslav G ChasnykDepartment of Hospital Pediatrics, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia.
Liora HarelPediatric Rheumatology Unit, Schneider Children's Medical Center, Petach-Tikvah, Israel.
Simone AppenzellerDepartment of Orthopedics, Rheumatology and Traumatology, School of Medical Science, University of Campinas, Campinas, Brazil.
Elisabeth GervaisRheumatology, Centre Hospitalier Universitaire (CHU) de Poitiers, Poitiers, France.
Sytze de RoockDepartment of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. box 85090, 3508 AB, Utrecht, The Netherlands.
Nico M WulffraatDepartment of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. box 85090, 3508 AB, Utrecht, The Netherlands.
Nicolino RupertoUOSID Centro trial, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Joost F SwartDepartment of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. box 85090, 3508 AB, Utrecht, The Netherlands.
Paediatric Rheumatology International Trials Organisation (PRINTO)
Utrecht University · NLIstituto Giannina Gaslini · ITCentre Hospitalier Universitaire de Poitiers · FRDanube Private University · ATSaint Petersburg State Pediatric Medical University · RUTel Aviv University · ILTogliatti State University · RUUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Applied Sciences Utrecht · NL

Funding

European Union 260353
6 · The paper itself

Abstract

backgroundLittle is known about the association between juvenile idiopathic arthritis (JIA) and autoimmune thyroid disease (AITD) and therefore there are no indications for AITD screening in this population, which is possible using standard blood tests. The objective of this study is to determine the prevalence and predictors of symptomatic AITD in JIA patients from the international Pharmachild registry.

methodsOccurrence of AITD was determined from adverse event forms and comorbidity reports. Associated factors and independent predictors for AITD were determined using univariable and multivariable logistic regression analyses.

resultsThe prevalence of AITD after a median observation period of 5.5 years was 1.1% (96/8965 patients). Patients who developed AITD were more often female (83.3% vs. 68.0%), RF positive (10.0% vs. 4.3%) and ANA positive (55.7% vs. 41.5%) than patients who did not. AITD patients were furthermore older at JIA onset (median 7.8 years vs. 5.3 years) and had more often polyarthritis (40.6% vs. 30.4%) and a family history of AITD (27.5% vs. 4.8%) compared to non-AITD patients. A family history of AITD (OR = 6.8, 95% CI: 4.1 - 11.1), female sex (OR = 2.2, 95% CI: 1.3 - 4.3), ANA positivity (OR = 2.0, 95% CI: 1.3 - 3.2) and older age at JIA onset (OR = 1.1, 95% CI: 1.1 - 1.2) were independent predictors of AITD on multivariable analysis. Based on our data, 16 female ANA positive JIA patients with a family history of AITD would have to be screened during ±5.5 years using standard blood tests to detect one case of AITD.

conclusionsThis is the first study to report independent predictor variables for symptomatic AITD in JIA. Female ANA positive JIA patients with positive family history are at increased risk of developing AITD and thus might benefit from yearly serological screening.

Indexed as

Arthritis, JuvenileThyroid DiseasesFemaleHumansMass ScreeningPrevalenceRegistriesAutoimmune thyroid diseaseEpidemiologyGraves’ diseaseHashimoto’s diseaseJuvenile idiopathic arthritisRegistryScreening

Identifiers

PMID36810111
PMCPMC9945712
OpenAlexW4321437913

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.