Evidence map›Paper›PMID 36810006›Full record

ArticleBMC oral health2023

Effect of systemic antiresorptive medication on the histopathological parameters of implant osseointegration in an in vivo rodent study.

Kristian Kniha, Benita Hermanns-Sachweh, Stephan Christian Möhlhenrich, Florian Peters, Marius Heitzer, Philipp Winnand, Frank Hölzle, Ali Modabber

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kristian KnihaDepartment of Oral and Cranio-Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. kkniha@ukaachen.de.
Benita Hermanns-SachwehPrivate Institute for Implant Pathology, ZBMT, Campus Melaten, Pauwelsstaße 17, Aachen, Germany.
Stephan Christian MöhlhenrichDepartment of Orthodontics, University of Witten/Herdecke, Alfred-Herrhausen Str. 45, 58455, Witten, Germany.
Florian PetersDepartment of Oral and Cranio-Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Marius HeitzerDepartment of Oral and Cranio-Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Philipp WinnandDepartment of Oral and Cranio-Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Frank HölzleDepartment of Oral and Cranio-Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Ali ModabberDepartment of Oral and Cranio-Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
RWTH Aachen University · DEWitten/Herdecke University · DE

Funding

START funding program of the medical faculty of Aachen University 105/18
6 · The paper itself

Abstract

backgroundThe purpose of this study was to evaluate the osseointegration of zirconia and titanium implants in the rat maxilla in specimens under systemic antiresorptive therapy. MATERIALS AND

methodsAfter 4 weeks of systematic medication administration (either zoledronic acid or alendronic acid), 54 rats received one zirconia and one titanium implants that were immediately inserted in the rat maxilla after tooth extraction. Twelve weeks after implant placement, histopathological samples were evaluated for implant osteointegration parameters.

resultsThe bone-implant-contact (BIC) ratio revealed no significant inter-group or inter-material differences. The distance between the implant shoulder to the bone level was significantly greater around the titanium implants of the zoledronic acid group compared to the zirconia implants of the control group (p = 0.0005). On average, signs of new bone formation could be detected in all groups, although often without statistical differences. Signs of bone necrosis were only detected around the zirconia implants of the control group (p < 0.05).

conclusionsAt the 3-month follow-up, no implant material was demonstrably better than the others in terms of osseointegration metrics under systemic antiresorptive therapy. Further studies are necessary to determine whether there are differences in the osseointegration behavior of the different materials.

Indexed as

Bone Density Conservation AgentsDental ImplantsAnimalsDental Prosthesis DesignMaxillaOsseointegrationRatsRodentiaSurface PropertiesTitaniumZirconiumZoledronic AcidBone Density Conservation AgentsDental ImplantsTitaniumZirconiumzirconium oxideZoledronic AcidBICBisphosphonateDental implantOsseointegrationTitaniumZirconia

Identifiers

PMID36810006
PMCPMC9945384
OpenAlexW4321434054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.