ArticleEnvironment international2023
The role of extreme heat exposure on premature rupture of membranes in Southern California: A study from a large pregnancy cohort.
Article in Environment international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- A systematic review and meta-analysis on heat thresholds for maternal health and birth outcomes.Nature communications · 2026Pooled it
- Thermal indices for assessing the impact of outdoor thermal environments on human health: a systematic review of epidemiological studies.International journal of biometeorology · 2025Pooled it
- Prediction of premature rupture of fetal membranes using deep learning in East China.Scientific reports · 2026Article
- Longer leukocyte telomere length increases the odds of premature rupture of membranes: a cross-sectional study based on UK Biobank.Scientific reports · 2026Article
- Applying a climate lens framework to the World Health Organization's maternal and perinatal intervention recommendations.Pregnancy (Hoboken, N.J.) · 2026Article
- Effect of non-optimal ambient temperature on preterm birth and its heterogeneity in various social sub-groups: a report from the Indo Gangetic Plains of India.BMC pregnancy and childbirth · 2026Article
- Temperature extremes and maternal health: differential risks of severe maternal morbidity during heatwaves and coldwaves in North Carolina.International journal of biometeorology · 2026Article
- Article
- Heat Waves and Early Birth: Exploring Vulnerability by Individual- and Area-Level Factors.GeoHealth · 2025Article
- Scoping review of climate drivers on maternal health: current evidence and clinical implications.AJOG global reports · 2025Review
- Associations of PMPeerJ · 2025Article
- Association of exposure to PMFrontiers in public health · 2025Article
- Utilizing the Health Belief Model to understand heat mitigation behaviors in the United States: Results of an online panel survey.PloS one · 2025Article
- Association of Postpartum Temperature Exposure with Postpartum Depression: A Retrospective Cohort Study in Southern California.Environmental health perspectives · 2024Article
- Maternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern China.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Preterm and Early-Term Delivery After Heat Waves in 50 US Metropolitan Areas.JAMA network open · 2024Article
- Analysis of Heat Exposure During Pregnancy and Severe Maternal Morbidity.JAMA network open · 2023Article
- Maternal exposure to ambient air pollution mixture and premature rupture of membranes: Evidence from a large cohort in Southern California (2008-2018).Environment international · 2023Article
- Impact of extreme heat and heatwaves on children's health: A scoping review.The journal of climate change and healthReview
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundSignificant mortality and morbidity in pregnant women and their offspring are linked to premature rupture of membranes (PROM). Epidemiological evidence for heat-related PROM risk is extremely limited. We investigated associations between acute heatwave exposure and spontaneous PROM.
methodsWe conducted this retrospective cohort study among mothers in Kaiser Permanente Southern California who experienced membrane ruptures during the warm season (May-September) from 2008 to 2018. Twelve definitions of heatwaves with different cut-off percentiles (75th, 90th, 95th, and 98th) and durations (≥ 2, 3, and 4 consecutive days) were developed using the daily maximum heat index, which incorporates both daily maximum temperature and minimum relative humidity in the last gestational week. Cox proportional hazards models were fitted separately for spontaneous PROM, term PROM (TPROM), and preterm PROM (PPROM) with zip codes as the random effect and gestational week as the temporal unit. Effect modification by air pollution (i.e., PM
resultsIn total, we included 190,767 subjects with 16,490 (8.6%) spontaneous PROMs. We identified a 9-14% increase in PROM risks associated with less intense heatwaves. Similar patterns as PROM were found for TPROM and PPROM. The heat-related PROM risks were greater among mothers exposed to a higher level of PM
conclusionUsing a rich and high-quality clinical database, we detected harmful heat exposure for spontaneous PROM in preterm and term deliveries. Some subgroups with specific characteristics were more susceptible to heat-related PROM risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.