Evidence map›Paper›PMID 36809647›Full record

Trial reportActa neurologica Belgica2023

Anti-spastic effect of contralesional dorsal premotor cortex stimulation in stroke patients with moderate-to-severe spastic paresis: a randomized, controlled pilot trial.

İlker Şengül, Ayhan Aşkın, Aylin Altun, Aliye Tosun

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Acta neurologica Belgica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04063995 (Effect of Repetitive Transcranial Magnetic Stimulation Over Contralesional Dorsal Premotor Cortex on Post Stroke Upper Limb Spasticity), which is not on this map. Cited by 5 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 4 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04063995 nacompletednot on this map

Effect of Repetitive Transcranial Magnetic Stimulation Over Contralesional Dorsal Premotor Cortex on Post Stroke Upper Limb Spasticity

TypeinterventionalSponsorIzmir Katip Celebi UniversityRan2019 to 2021Enrolled37ConditionsSpasticity as Sequela of StrokeArmsRepetitive transcranial magnetic stimulation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Efficacy of repetitive transcranial magnetic stimulation for post-stroke spasticity: a meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

İlker ŞengülDepartment of Physical Medicine and Rehabilitation, School of Medicine, İzmir Kâtip Çelebi University, Basın Sitesi Mahallesi Gazeteci Hasan Tahsin Caddesi, İzmir, Turkey. ilkrsngl@gmail.com.ORCID http://orcid.org/0000-0002-7675-7814
Ayhan AşkınDepartment of Physical Medicine and Rehabilitation, School of Medicine, İzmir Kâtip Çelebi University, Basın Sitesi Mahallesi Gazeteci Hasan Tahsin Caddesi, İzmir, Turkey.
Aylin AltunDepartment of Physical Medicine and Rehabilitation, School of Medicine, İzmir Kâtip Çelebi University, Basın Sitesi Mahallesi Gazeteci Hasan Tahsin Caddesi, İzmir, Turkey.
Aliye TosunDepartment of Physical Medicine and Rehabilitation, School of Medicine, İzmir Kâtip Çelebi University, Basın Sitesi Mahallesi Gazeteci Hasan Tahsin Caddesi, İzmir, Turkey.
Izmir Kâtip Çelebi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed at investigating the effect of a single-session repetitive transcranial magnetic stimulation (rTMS) of the contralesional dorsal premotor cortex on poststroke upper-limb spasticity. MATERIAL AND

methodsThe study consisted of the following three independent parallel arms: inhibitory rTMS (n = 12), excitatory rTMS (n = 12), and sham stimulation (n = 13). The primary and secondary outcome measures were the Modified Ashworth Scale (MAS) and F/M amplitude ratio, respectively. A clinically meaningful difference was defined as a reduction in at least one MAS score.

resultsThere was a statistically significant change in MAS score within only the excitatory rTMS group over time [median (interquartile range) of - 1.0 (- 1.0 to - 0.5), p = 0.004]. However, groups were comparable in terms of median changes in MAS scores (p > 0.05). The proportions of patients achieving at least one MAS score reduction (9/12 in the excitatory rTMS group, 5/12 in the inhibitory rTMS group, and 5/13 in the control group) were also comparable (p = 0.135). For the F/M amplitude ratio, main time effect, main intervention effect, and time-intervention interaction effect were not statistically significant (p > 0.05).

conclusionsModulation of the contralesional dorsal premotor cortex with a single-session of excitatory or inhibitory rTMS does not appear to have an immediate anti-spastic effect beyond sham/placebo. The implication of this small study remains unclear and further studies into excitatory rTMS for the treatment of moderate-to-severe spastic paresis in poststroke patients should be undertaken. CLINICAL TRIAL REGISTRATION NO: NCT04063995 (clinicaltrials.gov).

Indexed as

Motor CortexStrokeStroke RehabilitationHumansMuscle SpasticityParesisPilot ProjectsTranscranial Magnetic StimulationTreatment OutcomeDorsal premotor cortexMuscle spasticityRepetitive transcranial magnetic stimulationStroke

Identifiers

PMID36809647
OpenAlexW4321434912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.