Evidence map›Paper›PMID 36809642›Full record

ArticleInternational urology and nephrology2023

Treatment of localized prostate cancer in elderly patients: the role of partial cryoablation.

Oscar Selvaggio, Marco Finati, Ugo Giovanni Falagario, Giovanni Silecchia, Marco Recchia, Andrea Alberto Checchia, Paola Milillo, Francesca Sanguedolce, Luca Cindolo, Gian Maria Busetto and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International urology and nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. MR Imaging/Ultrasound Fusion-Guided Biopsy and Primary Focal Therapy for Localized Prostate Cancer.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Oscar SelvaggioDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Marco FinatiDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy. m.finati@outlook.it.ORCID http://orcid.org/0000-0002-7425-1166
Ugo Giovanni FalagarioDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Giovanni SilecchiaDepartment of Urology, Bonomo Teaching Hospital, Andria (BAT), Andria, Italy.
Marco RecchiaDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Andrea Alberto ChecchiaDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Paola MililloDepartment of Diagnostic Imaging, University of Foggia, Foggia, Italy.
Francesca SanguedolceDepartment of Pathology, University of Foggia, Foggia, Italy.
Luca CindoloDepartment of Urology, "Villa Stuart" Private Hospital, Rome, Italy.
Gian Maria BusettoDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Carlo BettocchiDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Luigi CormioDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
Giuseppe CarrieriDepartment of Urology and Organ Transplantation, University of Foggia, Foggia, Italy.
University of Foggia · ITOspedale L. Bonomo · ITVilla Torri Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate oncological outcomes of partial gland cryoablation (PGC) for localized prostate cancer (PCa) in a cohort of elderly patients who required an active treatment.

methodsData from 110 consecutive patients treated with PGC for localized PCa were collected. All patients underwent the same standardized follow-up with serum-PSA level and digital rectal examination. Prostate MRI and eventual re-biopsy were performed at twelve months after cryotherapy or in case of suspicion of recurrence. Biochemical recurrence was defined according to Phoenix criteria (PSA nadir + 2 ng/ml). Kaplan-Meier curves and Multivariable Cox Regression analyses were used to predict disease progression, biochemical recurrence- (BCS) and additional treatment-free survival (TFS).

resultsMedian age was 75 years (IQR 70-79). PGC was performed in 54 (49.1%) patients with low-risk PCa, 42 (38.1%) with intermediate risk and 14 (12.8%) high risk. At a median follow-up of 36 months, we recorded a BCS and TFS of 75 and 81%, respectively. At 5 years, BCS was 68.5% and CRS 71.5%. High-risk prostate cancer was associated with lower TFS and BCS curves when compared with low-risk group (all p values < .03). A PSA reduction < 50% between preoperative level and nadir resulted as an independent failure predictor for all outcomes evaluated (all p values < .01). Age was not associated with worse outcomes.

conclusionsPGC could be a valid treatment for low- to intermediate PCa in elderly patients, when a curative approach is suitable in terms of life expectancy and quality of life.

Indexed as

CryosurgeryProstatic NeoplasmsAgedHumansMaleNeoplasm Recurrence, LocalProstate-Specific AntigenQuality of LifeTreatment OutcomeProstate-Specific AntigenCryoablationFocal therapyGeriatric oncologyMinimally invasive surgeryProstate cancer

Identifiers

PMID36809642
PMCPMC10105669
OpenAlexW4321437652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.