Evidence map›Paper›PMID 36809416›Full record

ArticleLung2023

Association between serum Vitamin D levels and asthma severity and control in children and adolescents.

Ana Paula G Malheiro, Lívea Gianfrancesco, Roberto José N Nogueira, Milena B Grotta, André M Morcillo, José Dirceu Ribeiro, Adyléia A D C Toro

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  5. [Observation and analysis of Vitamin D levels in 147 children undergoing adenoidectomy and/or tonsillectomy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ana Paula G MalheiroChild and Adolescent Health Postgraduate Program, State University of Campinas, Campinas, Brazil. anamgaban@gmail.com.ORCID 0000-0002-7556-4893
Lívea GianfrancescoChild and Adolescent Health Postgraduate Program, State University of Campinas, Campinas, Brazil.ORCID 0000-0003-2963-8860
Roberto José N NogueiraDepartment of Pediatrics, School of Medical Sciences, State University of Campinas, Campinas, Brazil.ORCID 0000-0002-4833-3571
Milena B GrottaLaboratory of Pulmonary Physiology, School of Medical Sciences, Center for Investigation in Pediatrics, Universitária Zeferino Vaz, Tessália Vieira de Camargo Street, 126, Cidade, Campinas, São Paulo, 13083-887, Brazil.ORCID 0000-0002-1483-049X
André M MorcilloDepartment of Pediatrics, School of Medical Sciences, State University of Campinas, Campinas, Brazil.ORCID 0000-0002-2088-972X
José Dirceu RibeiroLaboratory of Pulmonary Physiology, School of Medical Sciences, Center for Investigation in Pediatrics, Universitária Zeferino Vaz, Tessália Vieira de Camargo Street, 126, Cidade, Campinas, São Paulo, 13083-887, Brazil.ORCID 0000-0002-3387-5642
Adyléia A D C ToroLaboratory of Pulmonary Physiology, School of Medical Sciences, Center for Investigation in Pediatrics, Universitária Zeferino Vaz, Tessália Vieira de Camargo Street, 126, Cidade, Campinas, São Paulo, 13083-887, Brazil.ORCID 0000-0001-5777-1146
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the association of serum Vitamin D (vitD) levels with asthma control and severity in children and adolescents in different seasons of the year.

methodLongitudinal, prospective study with 7- to 17-year-old children and adolescents diagnosed with asthma. All participants underwent two assessments conducted in opposite seasons of the year which included a clinical assessment, a questionnaire for classification of asthma control (Asthma Control Test), spirometry, and blood collection to measure serum vitD levels.

resultsIn total, 141 individuals with asthma were evaluated. The mean vitD was lower in females (p = 0.006) and sunlight exposure appears not to be an influencing factor for vitD levels. We found no differences in mean vitD of patients with controlled and uncontrolled asthma (p = 0.703; p = 0.956). However, the severe asthma group had lower mean Vitamin D than the mild/moderate asthma group for both assessments (p = 0.013; p = 0.032). In the first assessment, the group with vitD insufficiency had a higher prevalence of severe asthma (p = 0.015). Vitamin D was positively correlated with FEV

conclusionIn a tropical climate zone, there is no evidence of association between seasonality and serum vitD levels or between serum vitD levels and asthma control in children and adolescents. However, vitD and lung function were positively correlated and the group with vitD insufficiency had a higher prevalence of severe asthma.

Indexed as

AsthmaVitamin D DeficiencyAdolescentChildFemaleHumansLongitudinal StudiesProspective StudiesVitamin DVitaminsVitamin DVitamins25-hydroxyvitamin DAsthma Control TestChildLung functionSeasons

Identifiers

PMID36809416
OpenAlexW4321437624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.