Evidence map›Paper›PMID 36809393›Full record

ArticleAnnals of biomedical engineering2023

Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids.

Victoria L Thai, Diego O Candelas, J Kent Leach

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Victoria L ThaiDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, 95616, USA.ORCID http://orcid.org/0000-0003-1009-6432
Diego O CandelasDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, 95616, USA.
J Kent LeachDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, 95616, USA. jkleach@ucdavis.edu.ORCID http://orcid.org/0000-0002-1673-3335
University of California, Davis · USUC Davis Health · US

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Dual peptide presentation from bioengineered carriers to potentiate stromal cell function and tissue repairR01DE025899 · NIDCR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEACH, J. KENT · 2017 to 2021
$2.5M
Identifying the superior ossification pathway for tissue engineered approaches to long bone repairR01AR079211 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEACH, J. KENT · 2021 to 2025
$1.9M
Biomaterial regulation of cell spheroids to synergistically enhance bone healingR01DE025475 · NIDCR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEACH, J. KENT · 2015 to 2019
$1.9M
NHLBI NIH HHS T32 HL086350NIAMS NIH HHS R01 AR079211NIDCR NIH HHS R01 DE025475NIDCR NIH HHS R01 DE025899
6 · The paper itself

Abstract

Mesenchymal stromal cells (MSCs) are under investigation for wound healing and tissue regeneration due to their potent secretome. Compared to monodisperse cells, MSC spheroids exhibit increased cell survival and enhanced secretion of endogenous factors such as vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE

Indexed as

Mesenchymal Stem CellsSpheroids, CellularEndothelial CellsHumansHydrogelsVascular Endothelial Growth Factor AHydrogelsVascular Endothelial Growth Factor ADesign of experimentsEndothelial cellMesenchymal stromal cellPEG-4MALSpheroidsWound healing

Identifiers

PMID36809393
PMCPMC10264490
OpenAlexW4321437470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.