Evidence map›Paper›PMID 36809165›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

A SPECT-based method for dynamic imaging of the glymphatic system in rats.

Björn Sigurdsson, Natalie L Hauglund, Tuomas O Lilius, Frida L-H Mogensen, Kristian N Mortensen, Natalie Beschorner, Laura Klinger, Simone L Bærentzen, Marko P Rosenholm, Vladimir Shalgunov and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. The glymphatic system and glioblastoma.Brain : a journal of neurology · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Cerebrospinal fluid flow modulates brain health.The Journal of clinical investigation · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 4 countries.

Björn SigurdssonCenter for Translational Neuromedicine, University of Copenhagen, Denmark.ORCID 0000-0002-7484-7779
Natalie L HauglundCenter for Translational Neuromedicine, University of Copenhagen, Denmark.ORCID 0000-0002-2198-6329
Tuomas O LiliusCenter for Translational Neuromedicine, University of Copenhagen, Denmark.
Frida L-H MogensenCenter for Translational Neuromedicine, University of Copenhagen, Denmark.ORCID 0000-0002-3497-2321
Kristian N MortensenCenter for Translational Neuromedicine, University of Copenhagen, Denmark.
Natalie BeschornerCenter for Translational Neuromedicine, University of Copenhagen, Denmark.
Laura KlingerCenter for Translational Neuromedicine, University of Copenhagen, Denmark.
Simone L BærentzenTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Marko P RosenholmCenter for Translational Neuromedicine, University of Copenhagen, Denmark.ORCID 0000-0002-5437-8282
Vladimir ShalgunovDepartment of Drug Design and Pharmacology, University of Copenhagen, Denmark.
Matthias HerthDepartment of Drug Design and Pharmacology, University of Copenhagen, Denmark.
Yuki MoriCenter for Translational Neuromedicine, University of Copenhagen, Denmark.
Maiken NedergaardCenter for Translational Neuromedicine, University of Copenhagen, Denmark.
University of Copenhagen · DKAarhus University · DK

Funding

Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Patrick James Drew, Hajime Hirase · 2022 to 2026
$13.6M
The glymphatic system at the crossroad of integrative health approaches inchronic painR01AT011439 · NCCIH · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2021 to 2025
$3.1M
NCCIH NIH HHS R01 AT011439NINDS NIH HHS U19 NS128613
6 · The paper itself

Abstract

The glymphatic system is a brain-wide waste drainage system that promotes cerebrospinal fluid circulation through the brain to remove waste metabolites. Currently, the most common methods for assessing glymphatic function are

Indexed as

Glymphatic SystemAnimalsBrainMagnetic Resonance ImagingRatsSingle Photon Emission Computed Tomography Computed TomographyTomography, Emission-Computed, Single-Photon[111In]-DTPAcerebrospinal fluid dynamicslymph nodesrat brainWaste clearance

Identifiers

PMID36809165
PMCPMC10291457
OpenAlexW4321452644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.