Evidence map›Paper›PMID 36809068›Full record

ArticlemBio2023

Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves.

Manu Sharma, Hanbang Zhang, Gretchen Ehrenkaufer, Upinder Singh

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Manu SharmaDivision of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA.
Hanbang ZhangDivision of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA.
Gretchen EhrenkauferDivision of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA.
Upinder SinghDivision of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-0630-0306
Stanford University · US

Funding

Small RNA regulation of gene expression in EntamoebaR01AI121084 · NIAID · STANFORD UNIVERSITY · PI SINGH, UPINDER · 2016 to 2020
$3.1M
Extracellular vesicles, small RNAs, and intercellular communication in Entamoeba histolyticaR21AI125764 · NIAID · STANFORD UNIVERSITY · PI SINGH, UPINDER · 2016 to 2017
$435k
NIAID NIH HHS R01 AI121084NIAID NIH HHS R21 AI125764
6 · The paper itself

Abstract

tRNA-derived fragments have been reported in many different organisms and have diverse cellular roles, such as regulating gene expression, inhibiting protein translation, silencing transposable elements, and modulating cell proliferation. In particular, tRNA halves, a class of tRNA fragments produced by the cleavage of tRNAs in the anti-codon loop, have been widely reported to accumulate under stress and regulate translation in cells. Here, we report the presence of tRNA-derived fragments in

Indexed as

EntamoebaEntamoeba histolyticaArgonaute ProteinsRNA, TransferStress, PhysiologicalArgonaute ProteinsRNA, TransferencystationEntamoebatRNA-derived fragmentstRNA halves

Identifiers

PMID36809068
PMCPMC10127584
OpenAlexW4321446880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.