Evidence map›Paper›PMID 36808856›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Antioxidant Cascade Nanoenzyme Antagonize Inflammatory Pain by Modulating MAPK/p-65 Signaling Pathway.

Yuejuan Ling, Dekang Nie, Yue Huang, Mengyuan Deng, Qianqian Liu, Jinlong Shi, Siguang Ouyang, Yu Yang, Song Deng, Zhichao Lu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 52 citations in OpenAlex.

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  17. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yuejuan LingDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Dekang NieDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Yue HuangDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Mengyuan DengCenter for Advanced Low-dimension Materials, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, P. R. China.
Qianqian LiuDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Jinlong ShiDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Siguang OuyangDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Yu YangDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Song DengDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Zhichao LuDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Junling YangDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.
Yi WangCenter for Advanced Low-dimension Materials, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, P. R. China.ORCID 0000-0003-2904-6021
Rongqin HuangDepartment of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, 215537, P. R. China.
Wei ShiDepartment of Neurosurgery, Research Center of Clinical Medicine, Neuro-Microscopy and Minimally Invasive Translational Medicine Innovation Center, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University, 226001, Nantong, P. R. China.ORCID 0000-0003-4983-5255
Nantong University · CNDonghua University · CNFudan University · CN

Funding

333 high level talent project in Jiangsu Province BRA2019104Jiangsu Provincial Health Commission key projects ZDA2020009Jiangsu Provincial Science and Technology Department Social Development-Clinical Frontier Technology BE2020769Nantong Social and Livelihood Science and Technology key project MS22020017National Natural Science Foundation of China 31922044National Natural Science Foundation of China 81974453National Natural Science Foundation of China 82072778National Natural Science Foundation of China 82172746Natural Science Foundation of Shanghai 19ZR1471600Natural Science Foundation of Shanghai 20ZR1401800Program of Shanghai Academic Research Leader 20XD1420500
6 · The paper itself

Abstract

Chronic pain has attracted wide interest because it is a major obstacle affecting the quality of life. Consequently, safe, efficient, and low-addictive drugs are highly desirable. Nanoparticles (NPs) with robust anti-oxidative stress and anti-inflammatory properties possess therapeutic possibilities for inflammatory pain. Herein, a bioactive zeolitic imidazolate framework (ZIF)-8-capped superoxide dismutase (SOD) and Fe

Indexed as

AntioxidantsMitogen-Activated Protein KinasesAnimalsMicePainQuality of LifeSignal TransductionTumor Necrosis Factor-alphaAntioxidantsMitogen-Activated Protein KinasesTumor Necrosis Factor-alphabiomimetic nanoenzyme systeminflammatory painneuroinflammationreactive oxygen species scavenging

Identifiers

PMID36808856
PMCPMC10131840
OpenAlexW4321331004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.