ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Dementia occurring over a 32-year follow-up attributable to hypertension observed at different ages: Implications for dementia prevention.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Population attributable fractions of modifiable risk factors for dementia: a systematic review and meta-analysis.The lancet. Healthy longevity · 2024Pooled it
- Article
- Blood pressure polygenic score, cardiorespiratory fitness and odds of dementia: the HUNT Study.Age and ageing · 2026Article
- Correlation between the utilization of sodium-glucose cotransporter-2 (SGLT2) inhibitors and the risk of dementia: a nationwide population-based study in Taiwan.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Blood pressure and the brain: the conundrum of hypertension and dementia.Cardiovascular research · 2025Review
- The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Correlation between blood pressure control status and cognitive impairment in older adults: A national cross-sectional study.PloS one · 2025Article
- Association between coffee and tea consumption and the risk of dementia in individuals with hypertension: a prospective cohort study.Scientific reports · 2024Article
- Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection.Nature aging · 2024Article
- Associations and attributable burden between risk factors and all-cause and cause-specific mortality at different ages in patients with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- The need for a more holistic approach to dementia prevention.The lancet. Healthy longevity · 2024Article
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
introductionThe fraction of dementia attributable to hypertension might vary depending on the age of the population considered and the age through which dementia occurs.
methodsIn the Atherosclerosis Risk in Communities study, we quantified population attributable fractions (PAF) of dementia by age 80 and 90 from hypertension assessed at ages of 45-54 (n = 7572), 55-64 (n = 12,033), 65-74 (n = 6561), and 75-84 (n = 2086).
resultsThe PAF for dementia by age 80 from all non-normal blood pressure at ages 45-54 was 15.3% (95% confidence interval [CI] = 6.9%-22.3%), 19.1% (95% CI = 9.9%-26.9%) at ages 55-64, and 19.9% (95% CI = -4.4%-38.5%) at ages 65-74. The strongest PAFs were from stage 2 hypertension (11.9%-21.3%). For dementia by age 90, PAFs from non-normal blood pressure up through age 75 were smaller (10.9%-13.8%), and non-significant by age 75-84. DISCUSSION: Interventions targeting hypertension even in early late life might reduce a sizeable proportion of dementia. HIGHLIGHTS: We estimated prospective population attributable risks of dementia for hypertension. 15%-20% of dementia cases by age 80 are from non-normal blood pressure (BP). Associations between hypertension and dementia persisted through age 75. Midlife to early late-life BP control might reduce a large proportion of dementia.
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