Evidence map›Paper›PMID 36808764›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2023

Childhood sleep health and epigenetic age acceleration in late adolescence: Cross-sectional and longitudinal analyses.

David Balfour, Phillip E Melton, Joanne A McVeigh, Rae-Chi Huang, Peter R Eastwood, Sian Wanstall, Amy C Reynolds, Sarah Cohen-Woods

Open access · hybridAbstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

David BalfourCollege of Education, Psychology, and Social Work, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0002-5295-8806
Phillip E MeltonMenzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Joanne A McVeighCurtin School of Allied Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0002-2446-3814
Rae-Chi HuangNutrition and Health Innovation Research Institute (NHIRI), Edith Cowan University, Perth, Western Australia, Australia.
Peter R EastwoodFlinders Health and Medical Research Institute (Sleep Health), Flinders University, Adelaide, South Australia, Australia.
Sian WanstallFlinders Health and Medical Research Institute (Sleep Health), Flinders University, Adelaide, South Australia, Australia.
Amy C ReynoldsFlinders Health and Medical Research Institute (Sleep Health), Flinders University, Adelaide, South Australia, Australia.
Sarah Cohen-WoodsCollege of Education, Psychology, and Social Work, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0003-2199-6129
Flinders University · AUEdith Cowan University · AUUniversity of Tasmania · AUUniversity of the Witwatersrand · ZA

Funding

Flinders University Research Co-investment StrategyNational Health and Medical Research Council 003209National Health and Medical Research Council 1059711National Health and Medical Research Council 211912National Health and Medical Research Council 353514National Health and Medical Research Council 403981Raine Medical Research Foundation
6 · The paper itself

Abstract

aimInvestigate if childhood measures of sleep health are associated with epigenetic age acceleration in late adolescence.

methodsParent-reported sleep trajectories from age 5 to 17, self-reported sleep problems at age 17, and six measures of epigenetic age acceleration at age 17 were studied in 1192 young Australians from the Raine Study Gen2.

resultsThere was no evidence for a relationship between the parent-reported sleep trajectories and epigenetic age acceleration (p ≥ 0.17). There was a positive cross-sectional relationship between self-reported sleep problem score and intrinsic epigenetic age acceleration at age 17 (b = 0.14, p = 0.04), which was attenuated after controlling for depressive symptom score at the same age (b = 0.08, p = 0.34). Follow-up analyses suggested this finding may represent greater overtiredness and intrinsic epigenetic age acceleration in adolescents with higher depressive symptoms.

conclusionThere was no evidence for a relationship between self- or parent-reported sleep health and epigenetic age acceleration in late adolescence after adjusting for depressive symptoms. Mental health should be considered as a potential confounding variable in future research on sleep and epigenetic age acceleration, particularly if subjective measures of sleep are used.

Indexed as

DNA MethylationEpigenesis, GeneticAdolescentAustraliaChildChild, PreschoolHumansMental HealthSleepbiological agechildhoodDNA methylationmethylation agethe Raine Study

Identifiers

PMID36808764
PMCPMC10952569
OpenAlexW4321375243

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.