ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Hydrogel research in peripheral nerve injury repair: a comprehensive multi-database bibliometric analysis (2015-2025).Frontiers in neurologyPooled it
- Smart-responsive electrospun scaffolds (SRES) for neural repair: Recent advances and future prospects.Bioactive materials · 2026Review
- Piezoelectric Nanofibrous Scaffolds for Promoting the Growth of Spiral Ganglion Neurons via Acoustic Stimulation.Smart medicine · 2026Article
- Bioprinting the Craniofacial Region: A New Era in Regenerative Medicine and Dentistry.Journal of functional biomaterials · 2026Review
- A Microenvironment-Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances and Clinical Translation Potentials of Functional Nanomaterials in Tissue Engineering.Bioengineering (Basel, Switzerland) · 2026Review
- Hierarchical microtopology and phase-specific delivery functionally restore ultralong nerve continuity across species.Science advances · 2026Article
- Harnessing spatiotemporal melatonin delivery from engineered platforms for targeted microenvironment remodeling in peripheral neuropathy.Materials today. Bio · 2026Review
- A degradable PEGDA-dopamine hydrogel with ROS scavenging capacity supports flexible design for nerve repair.Materials today. Bio · 2026Article
- Re-innervation of neuromuscular junctions by a conductive polypyrrole/silk fibroin/GelMA hydrogel facilitated functional skeletal muscle regeneration following volumetric muscle loss.Journal of orthopaedic translation · 2026Article
- Fiber-integrated hydrogels: a versatile platform to improve structural and biological performance in 3D biofabrication.Materials today. Bio · 2026Review
- Three-Dimensional Printing of the Epineurium for Peripheral Nerve Repair: A Comprehensive Review of Novel Scaffolds for Nerve Conduits.Biomimetics (Basel, Switzerland) · 2026Review
- Three-tier framework for high-throughput biofabrication: Integrating 3D bioprinting, assistive platforms, and translational opportunities.Bioactive materials · 2026Review
- Magnetic graphene oxide functionalized composite nanofibrous stem cell-based neural scaffolds.Journal of nanobiotechnology · 2026Article
- Biocompatible, Ion-Conductive Hydrogel-Filled Nerve Conduit for Peripheral Nerve Regeneration.ACS applied materials & interfaces · 2026Article
- Engineering 3D-printed standalone conductive nerve guides using soft bioinks for peripheral nerve injuries.Materials advances · 2026Article
- Nano-Immunomodulators for Directing Macrophage Fate to Enhance Peripheral Nerve Repair: Advances, Challenges, and Translational Perspectives.International journal of nanomedicine · 2026Review
- Topology-optimized melt-electrowritten PCL patch for abdominal wall reconstruction.Bioactive materials · 2026Article
- Nanomaterial-Enhanced Conductive Hydrogels for Peripheral Nerve Repair: Biomimetic Design, Mechanisms, and Translational Challenges.International journal of nanomedicine · 2026Review
- Research Progress in Thermal Functional Fibers.Materials (Basel, Switzerland) · 2025Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of nerve regeneration and functional recovery is greatly affected by the physical, chemical, and electrical properties of NGCs. In this study, a conductive multiscale filled NGC (MF-NGC) consisting of electrospun poly(lactide-co-caprolactone) (PCL)/collagen nanofibers as the sheath, reduced graphene oxide /PCL microfibers as the backbone, and PCL microfibers as the internal structure for peripheral nerve regeneration is developed. The printed MF-NGCs presented good permeability, mechanical stability, and electrical conductivity, which further promoted the elongation and growth of Schwann cells and neurite outgrowth of PC12 neuronal cells. Animal studies using a rat sciatic nerve injury model reveal that the MF-NGCs promote neovascularization and M2 transition through the rapid recruitment of vascular cells and macrophages. Histological and functional assessments of the regenerated nerves confirm that the conductive MF-NGCs significantly enhance peripheral nerve regeneration, as indicated by improved axon myelination, muscle weight increase, and sciatic nerve function index. This study demonstrates the feasibility of using 3D-printed conductive MF-NGCs with hierarchically oriented fibers as functional conduits that can significantly enhance peripheral nerve regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.