Evidence map›Paper›PMID 36808599›Full record

ArticleJournal of neuro-oncology2023

The characteristics of brain structural remodeling in patients with unilateral vestibular schwannoma.

Hanlu Tang, Zhixu Bie, Bo Wang, Zhijun Yang, Peng Li, Xingchao Wang, Pinan Liu

Erratum issuedAbstract read
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In one paragraph

Article in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hanlu TangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Zhixu BieDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Bo WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Zhijun YangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Peng LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Xingchao WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. wangxc@mail.ccmu.edu.cn.
Pinan LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. pinanliu@ccmu.edu.cn.
Capital Medical University · CNBeijing Tian Tan Hospital · CN

Funding

the Platform Construction of Basic Research and Clinical Translation of Nervous System Injury (2020) PXM2020_026280_000002
6 · The paper itself

Abstract

purposeBrain structural remodeling alters related brain function. However, few studies have assessed morphological alterations of unilateral vestibular schwannoma (VS) patients. Therefore, this study examined the characteristics of brain structural remodeling in unilateral VS patients.

methodsWe recruited 39 patients with unilateral VS (19 left, 20 right) and 24 matched normal controls (NCs). We obtained brain structural imaging data using 3T T1-weighted anatomical and diffusion tensor imaging scans. Then, we evaluated both gray and white matter (WM) changes using FreeSurfer software and tract-based spatial statistics, respectively. Furthermore, we constructed a structural covariance network to assess brain structural network properties and the connectivity strength between brain regions.

resultsCompared with NCs, VS patients showed cortical thickening in non-auditory areas (e.g., the left precuneus), especially left VS patients, along with reduced cortical thickness in the right superior temporal gyrus (auditory areas). VS patients also showed increased fractional anisotropy in extensive non-auditory-related WM (e.g., the superior longitudinal fasciculus), especially right VS patients. Both left and right VS patients showed increased small-worldness (more efficient information transfer). Left VS patients had a single reduced-connectivity subnetwork in contralateral temporal regions (right-side auditory areas), but increased connectivity between some non-auditory regions (e.g., left precuneus and left temporal pole).

conclusionVS patients exhibited greater morphological alterations in non-auditory than auditory areas, with structural reductions seen in related auditory areas and a compensatory increase in non-auditory areas. Left and right VS patients show differential patterns of brain structural remodeling. These findings provide a new perspective on the treatment and postoperative rehabilitation of VS.

Indexed as

Neuroma, AcousticWhite MatterAnisotropyBrainDiffusion Tensor ImagingHumansMagnetic Resonance ImagingCortical thicknessStructural covariance networksVestibular schwannomaWhite matter

Identifiers

PMID36808599
OpenAlexW4321478477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.