ArticleInterdisciplinary cardiovascular and thoracic surgery2023
Predictive factors for postoperative myasthenic crisis in patients with myasthenia gravis.
Article in Interdisciplinary cardiovascular and thoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Perioperative use of eculizumab in patients with thymoma-associated myasthenia gravis: A preliminary case series of five patients.IBRO neuroscience reports · 2026Article
- Thymectomy in Ocular Myasthenia Gravis: Results Before and After Generalization and Prognostic Predictors of Outcomes.Journal of clinical medicine · 2025Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesThymectomy plays an important role in the comprehensive treatment of myasthenia gravis. The present study aimed to investigate the risk factors for postoperative myasthenic crisis (POMC) in these patients and then establish a predicting model based on preoperatively available indicators.
methodsThe clinical records of 177 consecutive patients with myasthenia gravis who received extended thymectomy between January 2018 and September 2022 in our department were retrospectively reviewed. Patients were divided into 2 groups according to whether they developed POMC. Univariate and multivariate regression analyses were conducted to identify the independent risk factors of POMC. Then a nomogram was constructed to intuitively show the results. Finally, the calibration curve and bootstrap resampling were used to evaluate its performance.
resultsPOMC occurred in 42 (23.7%) patients. By multivariate analysis, body mass index (P = 0.029), Osserman classification (P = 0.015), percentage of predicted forced vital capacity (pred%) (P = 0.044), percentage of predicted forced expiratory volume in the first second (pred%) (P = 0.043) and albumin to globulin ratio (P = 0.009) were identified as independent risk factors and entered into the nomogram. The calibration curve showed good concordance between the predicted and actual probability of prolonged ventilation.
conclusionsOur model is a valuable tool for predicting POMC in myasthenia gravis patients. For those high-risk patients, appropriate preoperative treatment is necessary to improve the symptoms and greater attention to postoperative complications is needed.
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