Evidence map›Paper›PMID 36808103›Full record

ArticleDementia and geriatric cognitive disorders2023

Systolic Blood Pressure Is Associated with Increased Brain Amyloid Load in Mild Cognitively Impaired Participants: Alzheimer's Disease Neuroimaging Initiatives Study.

Thomas V Fungwe, Julius S Ngwa, Steven P Johnson, Jilian V Turner, Mara I Ramirez Ruiz, Oludolapo O Ogunlana, Fikru B Bedada, Sheeba Nadarajah, Oyonumo E Ntekim, Thomas O Obisesan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Thomas V FungweDepartment of Nutritional Sciences, College of Nursing and Allied Health Sciences, Howard University, Washington, District of Columbia, USA.
Julius S NgwaDivision of Cardiology, Department of Medicine, Howard University, Washington, District of Columbia, USA.
Steven P JohnsonDivision of Geriatrics, Department of Internal Medicine, Howard University Hospital, Washington, District of Columbia, USA.
Jilian V TurnerDivision of Geriatrics, Department of Internal Medicine, Howard University Hospital, Washington, District of Columbia, USA.
Mara I Ramirez RuizDivision of Geriatrics, Department of Internal Medicine, Howard University Hospital, Washington, District of Columbia, USA.
Oludolapo O OgunlanaDivision of Geriatrics, Department of Internal Medicine, Howard University Hospital, Washington, District of Columbia, USA.
Fikru B BedadaDepartment of Clinical Laboratory Sciences, College of Nursing and Allied Health Sciences, Howard University, Washington, District of Columbia, USA.
Sheeba NadarajahDepartment of Nursing, College of Nursing and Allied Health Sciences, Howard University, Washington, District of Columbia, USA.
Oyonumo E NtekimDepartment of Nutritional Sciences, College of Nursing and Allied Health Sciences, Howard University, Washington, District of Columbia, USA.
Thomas O ObisesanDivision of Geriatrics, Department of Internal Medicine, Howard University Hospital, Washington, District of Columbia, USA.
Howard University · USHoward University Hospital · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUUL1TR000101 · NCATS · GEORGETOWN UNIVERSITY · PI MELLMAN, THOMAS A, VERBALIS, JOSEPH G · 2012 to 2015
$19.3M
Genes, Exercise, Neurocognitive and Neurodegeneration: Community-Based ApproachR01AG045058 · NIA · HOWARD UNIVERSITY · PI OBISESAN, THOMAS O · 2014 to 2018
$2.9M
Effects of Standardized Aerobic Exercise-Training on Neurocognitive and NeurodegeR01AG031517 · NIA · HOWARD UNIVERSITY · PI OBISESAN, THOMAS O · 2009 to 2010
$2.0M
NCATS NIH HHS UL1 TR000101NIA NIH HHS R01 AG031517NIA NIH HHS R01 AG045058NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD), including elevated blood pressure (BP), is known to promote Alzheimer's disease (AD) risk. Although brain amyloid load is a recognized hallmark of pre-symptomatic AD, its relationship to increased BP is less known. The objective of this study was to examine the relationship of BP to brain estimates of amyloid-β (Aβ) and standard uptake ratio (SUVr). We hypothesized that increased BP is associated with increased SUVr.

methodsUsing data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we stratified BP according to the Seventh Joint National Committee (JNC) on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure Classification (JNC VII). Florbetapir (AV-45) SUVr was derived from the averaged frontal, anterior cingulate, precuneus, and parietal cortex relative to the cerebellum. A linear mixed-effects model enabled the elucidation of amyloid SUVr relationships to BP. The model discounted the effects of demographics, biologics, and diagnosis at baseline within APOE genotype groups. The least squares means procedure was used to estimate the fixed-effect means. All analyses were performed using the Statistical Analysis System (SAS).

resultsIn non-ɛ4 carrier MCI subjects, escalating JNC categories of BP was associated with increasing mean SUVr using JNC-4 as a reference point (low-normal (JNC1) p = 0.018; normal (JNC-1) p = 0.039; JNC-2 p = 0.018 and JNC-3 p = 0.04). A significantly higher brain SUVr was associated with increasing BP despite adjustment for demographics and biological variables in non-ɛ4 carriers but not in ɛ4-carriers. This observation supports the view that CVD risk may promote increased brain amyloid load, and potentially, amyloid-mediated cognitive decline.

conclusionIncreasing levels of JNC classification of BP is dynamically associated with significant changes in brain amyloid burden in non-ɛ4 carriers but not in ɛ4-carrier MCI subjects. Though not statistically significant, amyloid burden tended to decrease with increasing BP in ɛ4 homozygote, perhaps motivated by increased vascular resistance and the need for higher brain perfusion pressure.

Indexed as

Alzheimer DiseaseCardiovascular DiseasesCognitive DysfunctionAmyloidAmyloid beta-PeptidesBlood PressureBrainHumansNeuroimagingPositron-Emission TomographyAmyloidAmyloid beta-PeptidesA-beta-amyloidAlzheimer’s diseaseApolipoproteinBlood pressureMild cognitive impairment

Identifiers

PMID36808103
PMCPMC10219843
OpenAlexW4321367110

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.