SynthesisHuman brain mapping2023
Dysfunctions associated with the intraparietal sulcus and a distributed network in individuals with math learning difficulties: An ALE meta-analysis.
Synthesis in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Dysfunctions associated with the intraparietal sulcus and a distributed network in individuals with math learning difficulties: An ALE meta-analysis.Human brain mapping · 2023Pooled it
- Enhancing mathematical skills in children with dyscalculia: the effects of transcranial photobiomodulation.Lasers in medical science · 2025Trial
- The interplay between executive function and learning disabilities: Developmental cognitive neuroscience perspectives on reading, math, and ADHD.Developmental cognitive neuroscience · 2026Review
- Space and time in words: exploring neural overlap and specificity.Behavioral and brain functions : BBF · 2025Article
- Children identified for classroom-based math support show altered resting-state connectivity in parietal brain regions.Scientific reports · 2025Article
- Altered Effective Connectivity of the Numerical Brain in Children With Developmental Dyscalculia.Journal of neuroscience research · 2025Article
- Personalized deep neural networks reveal mechanisms of math learning disabilities in children.Science advances · 2025Article
- Article
- Predictive modeling of significance thresholding in activation likelihood estimation meta-analysis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Brain network of athletes in motor imagery and action anticipation: an ALE meta-analysis and MACM analysis.Frontiers in sports and active living · 2025Review
- Clinical implications of brain asymmetries.Nature reviews. Neurology · 2024Review
- Digital twins for understanding mechanisms of learning disabilities: Personalized deep neural networks reveal impact of neuronal hyperexcitability.bioRxiv : the preprint server for biology · 2024Article
- Activation and functional connectivity of cerebellum during reading and during arithmetic in children with combined reading and math disabilities.Frontiers in neuroscience · 2024Article
- Developmental dyscalculia is not associated with atypical brain activation: A univariate fMRI study of arithmetic, magnitude processing, and visuospatial working memory.Human brain mapping · 2023Article
- The brain lateralization and development of math functions: progress since Sperry, 1974.Frontiers in human neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Math learning difficulty (MLD) is a learning disorder characterized by persistent impairments in the understanding and application of numbers independent of intelligence or schooling. The current study aims to review existing neuroimaging studies to characterize the neurobiological basis in MLD for their quantity and arithmetic dysfunctions. We identified a total of 24 studies with 728 participants through the literature. Using the activation likelihood estimate (ALE) method, we found that the most consistent neurobiological dysfunction in MLD was observed in the right intraparietal sulcus (IPS) with distinct patterns of the anterior and posterior aspects. Meanwhile, neurobiological dysfunctions were also observed in a distributed network including the fusiform gyrus, inferior temporal gyrus, insula, prefrontal cortex, anterior cingulate cortex, and claustrum. Our results suggest a core dysfunction in the right anterior IPS and left fusiform gyrus with atypically upregulated functions in brain regions for attention, working memory, visual processing, and motivation, serving as the neurobiological basis of MLD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.