ArticleNature medicine2023
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation.
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Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
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105citing papers in PubMed, 1 pooled it
20.7field-weighted citation impact, top 1% of its field
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Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.
- A Systematic Review and Meta-Analysis on the Impact of Statin Treatment in HIV Patients on Antiretroviral Therapy.International journal of environmental research and public health · 2023Pooled it
- Virological and Immunological Outcomes of Combined Therapeutic Interventions and Dendritic Cell Therapy in People With HIV.The Journal of infectious diseases · 2025Trial
- HLA-mismatched allogeneic adoptive immune therapy in patients with severely immunosuppressed AIDS: a multicenter, open-label, controlled, phase 2a study.Emerging microbes & infections · 2024Trial
- Engineering hematopoietic stem and progenitor cells to generate red blood cells as viral traps against HIV-1.Molecular therapy. Advances · 2026Article
- Emerging CCR5-Based Therapeutic Potential of JAK/STAT Inhibitors and CCR5Δ32 Hematopoietic Stem Cell Transplantation.Viruses · 2026Review
- Development of an investigational medicinal stem cell gene therapy product to attempt curing human immunodeficiency virus infection.Scientific reports · 2026Article
- HIV cure after HCT: 7 horses seem to be on the mark.Blood advances · 2026Article
- Opportunities and challenges in achieving a functional cure for HIV.Infectious diseases & immunity · 2026Review
- Review
- Preparation, Oral SNEDDS Formulation, and In Vivo Evaluation of the HIV-1 Latency-Reversing Agent EK-16A.Molecules (Basel, Switzerland) · 2026Article
- Acute myeloid leukemia in HIV-positive patients: biological crossroads and therapeutic Hurdles.Clinical and experimental medicine · 2026Review
- Long-term HIV-1 remission achieved through allogeneic haematopoietic stem cell transplant from a CCR5Δ32/Δ32 sibling donor.Nature microbiology · 2026Article
- Boosting prime editing with engineered non-canonical pegRNAs.Nature biomedical engineering · 2026Article
- Sex-Specific Factors Influencing HIV Infection.Immunological reviews · 2026Review
- From bench to bedside: stem cell therapy as a transformative approach against HIV.Molecular biology reports · 2026Review
- HBsAg loss in recipients with chronic hepatitis B after allogeneic hematopoietic stem-cell transplantation: a retrospective cohort study exploring kinetic dynamics.BMC infectious diseases · 2026Article
- Epigenetic mechanisms of retroviral regulation: a comparative review.Epigenetics & chromatin · 2026Review
- Article
- Safety and biologic activity of a bispecific T cell receptor targeting HIV Gag in males living with HIV: a first-in-human trial.Nature communications · 2026Article
- HIV-Associated Lymphomas: Updates from Pathogenesis to Treatment Strategies.Current HIV research · 2026Review
45 more citing papers are in PubMed but not listed here.
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Authors and funding
36 authors at 13 institutions in 7 countries.
Björn-Erik Ole Jensen *Department of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. bjoern-erikole.jensen@med.uni-duesseldorf.de.ORCID http://orcid.org/0000-0003-1626-4855
Elena Knops *Institute of Virology, University and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-7398-3026
Leon Cords *Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-1340-8817
Nadine Lübke *Institute of Virology, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Maria Salgado *IrsiCaixa AIDS Research Institute, Barcelona, Spain.ORCID http://orcid.org/0000-0003-1551-7216
Kathleen Busman-SahayVaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.ORCID http://orcid.org/0000-0002-8549-0023
Jacob D EstesVaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.
Laura E P HuyveneersTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Federico Perdomo-CelisInstitut Pasteur, Paris Cité University, HIV Inflammation and Persistence, Paris, France.
Melanie WittnerInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Cristina GálvezIrsiCaixa AIDS Research Institute, Barcelona, Spain.
Christiane MummertInfectious Diseases and Immunodeficiency Section, Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Caroline PassaesInstitut Pasteur, Paris Cité University, HIV Inflammation and Persistence, Paris, France.ORCID http://orcid.org/0000-0002-0813-2521
Johanna M EberhardInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-8367-3870
Carsten MünkDepartment of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Ilona HauberLeibniz Institute of Virology, Hamburg, Germany.
Joachim HauberGerman Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Eva HegerInstitute of Virology, University and University Hospital Cologne, University of Cologne, Cologne, Germany.
Jozefien De ClercqHIV Cure Research Center and Department of General Internal Medicine and Infectious Diseases, Ghent University Hospital, Ghent, Belgium.
Linos VandekerckhoveHIV Cure Research Center and Department of General Internal Medicine and Infectious Diseases, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0002-8600-1631
Silke BergmannInfectious Diseases and Immunodeficiency Section, Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Gábor A DunayGerman Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Florian KleinInstitute of Virology, University and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0003-1376-1792
Dieter HäussingerDepartment of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-5936-682X
Johannes C FischerInstitute for Transplant Diagnostics and Cell Therapeutics, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Kathrin NachtkampDepartment of Hematology, Oncology and Clinical Immunology, Medical Faculty, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany.
Joerg TimmInstitute of Virology, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-7799-3045
Rolf KaiserInstitute of Virology, University and University Hospital Cologne, University of Cologne, Cologne, Germany.
Thomas HarrerInfectious Diseases and Immunodeficiency Section, Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Tom LueddeDepartment of Gastroenterology, Hepatology and Infectious Diseases, Düsseldorf University Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-6288-8821
Monique NijhuisTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0001-6610-8282
Asier Sáez-CiriónInstitut Pasteur, Paris Cité University, HIV Inflammation and Persistence, Paris, France.ORCID http://orcid.org/0000-0003-2406-7536
Julian Schulze Zur WieschInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. j.schulze-zur-wiesch@uke.de.ORCID http://orcid.org/0000-0002-5033-1938
Annemarie M J WensingTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Javier Martinez-PicadoIrsiCaixa AIDS Research Institute, Barcelona, Spain.ORCID http://orcid.org/0000-0002-4916-2129
Guido KobbeDepartment of Hematology, Oncology and Clinical Immunology, Medical Faculty, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany.
Düsseldorf University Hospital · DEUniversität Hamburg · DEUniversity of Cologne · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEInstitut Pasteur · FRLeibniz Institute of Virology (LIV) · DEGhent University Hospital · BEOregon National Primate Research Center · USUniversity Medical Center Utrecht · NLInstituto de Salud Carlos III · ESIrsiCaixa · ESUniversitat de Vic - Universitat Central de Catalunya · ESUniversity of the Witwatersrand · ZA
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MReversing Immune Dysfunction for HIV-1 EradicationUM1AI164561 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SUMIT K CHANDA, Paula M Cannon · 2021 to 2026
$30.0MNovel ISH Approaches to Quantify Replication Competent ReservoirsR01AI143411 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI ESTES, JACOB D · 2019 to 2023
$3.6MNIAID NIH HHS R01 AI143411NIAID NIH HHS UM1 AI164561NIH HHS P51 OD011092
Abstract
Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human immunodeficiency virus type 1 (HIV-1), the knowledge of immunological and virological correlates of cure is limited. Here we characterize a case of long-term HIV-1 remission of a 53-year-old male who was carefully monitored for more than 9 years after allogeneic CCR5Δ32/Δ32 HSCT performed for acute myeloid leukemia. Despite sporadic traces of HIV-1 DNA detected by droplet digital PCR and in situ hybridization assays in peripheral T cell subsets and tissue-derived samples, repeated ex vivo quantitative and in vivo outgrowth assays in humanized mice did not reveal replication-competent virus. Low levels of immune activation and waning HIV-1-specific humoral and cellular immune responses indicated a lack of ongoing antigen production. Four years after analytical treatment interruption, the absence of a viral rebound and the lack of immunological correlates of HIV-1 antigen persistence are strong evidence for HIV-1 cure after CCR5Δ32/Δ32 HSCT.
Indexed as
Hematopoietic Stem Cell TransplantationHIV-1HIV InfectionsAnimalsHumansMaleMiceMiddle Aged
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