Evidence map›Paper›PMID 36807589›Full record

ArticleJournal of veterinary internal medicine2023

Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease.

Rene E Paschall, Jessica M Quimby, Rachel E Cianciolo, Shannon M McLeland, Katharine F Lunn, Jonathan Elliott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rene E PaschallDepartment of Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio, USA.
Jessica M QuimbyDepartment of Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-1388-0452
Rachel E CiancioloDepartment of Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio, USA.
Shannon M McLelandDepartment of Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio, USA.
Katharine F LunnDepartment of Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-7083-5861
Jonathan ElliottDepartment of Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-4517-6590
The Ohio State University · US

Funding

Buttons Fund for Feline Chronic Kidney Disease Research Not applicable
6 · The paper itself

Abstract

backgroundHypoxia is a key driver of fibrosis and is associated with capillary rarefaction in humans.

objectivesCharacterize capillary rarefaction in cats with chronic kidney disease (CKD). ANIMALS: Archival kidney tissue from 58 cats with CKD, 20 unaffected cats.

methodsCross-sectional study of paraffin-embedded kidney tissue utilizing CD31 immunohistochemistry to highlight vascular structures. Consecutive high-power fields from the cortex (10) and corticomedullary junction (5) were digitally photographed. An observer counted and colored the capillary area. Image analysis was used to determine the capillary number, average capillary size, and average percent capillary area in the cortex and corticomedullary junction. Histologic scoring was performed by a pathologist masked to clinical data.

resultsPercent capillary area (cortex) was significantly lower in CKD (median 3.2, range, 0.8-5.6) compared to unaffected cats (4.4, 1.8-7.0; P = <.001) and was negatively correlated with serum creatinine concentrations (r = -.36, P = .0013), glomerulosclerosis (r = -0.39, P = <.001), inflammation (r = -.30, P = .009), and fibrosis (r = -.30, P = .007). Capillary size (cortex) was significantly lower in CKD cats (2591 pixels, 1184-7289) compared to unaffected cats (4523 pixels, 1801-7618; P = <.001) and was negatively correlated with serum creatinine concentrations (r = -.40, P = <.001), glomerulosclerosis (r = -.44, P < .001), inflammation (r = -.42, P = <.001), and fibrosis (r = -.38, P = <.001). CONCLUSIONS AND CLINICAL IMPORTANCE: Capillary rarefaction (decrease in capillary size and percent capillary area) is present in kidneys of cats with CKD and is positively correlated with renal dysfunction and histopathologic lesions.

Indexed as

Cat DiseasesMicrovascular RarefactionRenal Insufficiency, ChronicAnimalsCatsCreatinineCross-Sectional StudiesFibrosisHumansInflammationKidneyCreatininecapillary densityCD31chronic renal diseasefeline

Identifiers

PMID36807589
PMCPMC10061179
OpenAlexW4321330719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.