ArticleCommunications biology2023
A heterophil/lymphocyte-selected population reveals the phosphatase PTPRJ is associated with immune defense in chickens.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Gut microbial community assembly exhibits compartment-specific responses to selection for high body weight in female chickens.Poultry science · 2026Article
- Hepatic immunometabolic signatures associated with the heterophil-to-lymphocyte ratio reveal sex-dependent patterns in yellow-legged ma chickens.Poultry science · 2026Article
- Corticosterone reprograms splenic responses to avian pathogenic Escherichia coli infection in broiler chickens.Poultry science · 2025Article
- Single-cell RNA sequencing of the spleen reveals differences in Salmonella typhimurium infection mechanisms between different chicken breeds.Poultry science · 2025Article
- Endocrine and molecular regulation of seasonal avian immune function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Disease resistance traits of IPB-D2 chickens: Characterization of IgY concentrations, Newcastle disease antibody titers, and leukocyte profiles.Veterinary world · 2025Article
- Spray-Dried Plasma Promotes Broiler Chick Growth by Enhancing Immune Surveillance.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantification of leukocyte profiles is among the simplest measures of animal immune function. However, the relationship between H/L ratio and innate immunity and the measure's utility as an index for heterophil function remains to be analyzed. Variants associated with H/L ratio were fine-mapped based on the resequencing of 249 chickens of different generations and an F2 segregating population generated by crossing selection and control lines. H/L ratio in the selection line was associated with a selective sweep of mutations in protein tyrosine phosphatase, receptor type J (PTPRJ), which affects proliferation and differentiation of heterophils through its downstream regulatory genes. The SNP downstream of PTPRJ (rs736799474) have a universal effect on H/L, with CC homozygotes exhibiting improved heterophil function because of downregulated PTPRJ expression. In short, we systematically elucidated the genetic basis of the change in heterophil function resulting from H/L selection by identifying the regulatory gene (PTPRJ) and causative SNP.
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