Evidence map›Paper›PMID 36806996›Full record

ArticleOphthalmology and therapy2023

Correlation Between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Retinal Vein Occlusion.

Dimitrios Kazantzis, Theodoros N Sergentanis, Genovefa Machairoudia, Eleni Dimitriou, Christos Kroupis, George Theodossiadis, Panagiotis Theodossiadis, Irini Chatziralli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Faricimab: current evidence for the treatment of retinal vein occlusion.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dimitrios Kazantzis *2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, 1, Rimini Street, 12462, Haidari, Greece.
Theodoros N Sergentanis *Department of Clinical Therapeutics, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Genovefa Machairoudia2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, 1, Rimini Street, 12462, Haidari, Greece.
Eleni Dimitriou2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, 1, Rimini Street, 12462, Haidari, Greece.
Christos KroupisDepartment of Clinical Biochemistry, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
George Theodossiadis2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, 1, Rimini Street, 12462, Haidari, Greece.
Panagiotis Theodossiadis2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, 1, Rimini Street, 12462, Haidari, Greece.
Irini Chatziralli2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, 1, Rimini Street, 12462, Haidari, Greece. eirchat@yahoo.gr.ORCID http://orcid.org/0000-0001-8523-1024
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to investigate the possible correlation between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with retinal vein occlusion (RVO).

methodsParticipants in this cross-sectional observational study were 65 consecutive patients (65 eyes) with treatment-naïve RVO, who underwent spectral-domain optical coherence tomography (SD-OCT) and fundus fluorescein angiography (FFA). In addition, peripheral blood samples were taken to evaluate full blood count and biochemical parameters. The association between imaging characteristics and laboratory parameters was examined.

resultsEyes with subretinal fluid presented significantly higher neutrophil-to-lymphocyte ratios (p = 0.028). Hyperreflective foci on SD-OCT were found to be associated with higher triglyceride levels (p = 0.024). The presence of cysts on SD-OCT was associated with significantly higher triglycerides (p = 0.010). Central subfield thickness (CST) higher than 464 μm was associated with higher lymphocyte count (p = 0.016) and higher urea (p = 0.015). No significant associations were found between laboratory parameters and intraretinal fluid, ellipsoid zone and external limiting membrane condition, or epiretinal membrane and macular ischemia.

conclusionsSpecific imaging morphological characteristics were found to be associated with laboratory parameters in patients with RVO. These findings may help reveal the pathophysiology of RVO and its correlation with the development of specific clinical signs, while they could guide individualized treatment.

Indexed as

BiochemicalBlood countLaboratoryOptical coherence tomographyRetinal vein occlusion

Identifiers

PMID36806996
PMCPMC10011245
OpenAlexW4321326049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.