Evidence map›Paper›PMID 36806835›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Reactivities of α-Oxo BMIDA Gold Carbenes Generated by Gold-Catalyzed Oxidation of BMIDA-Terminated Alkynes.

Yang Zheng, Jingxing Jiang, Yue Li, Yongliang Wei, Junqi Zhang, Jundie Hu, Zhuofeng Ke, Xinfang Xu, Liming Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yang ZhengDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
Jingxing JiangSchool of Materials Science & Engineering, PCFM Lab, Sun Yat-sen University, Guangzhou, 510275, P. R. China.
Yue LiDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
Yongliang WeiDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
Junqi ZhangDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
Jundie HuSchool of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215009, P. R. China.
Zhuofeng KeSchool of Materials Science & Engineering, PCFM Lab, Sun Yat-sen University, Guangzhou, 510275, P. R. China.
Xinfang XuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Liming ZhangDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.ORCID http://orcid.org/0000-0002-5306-1515
University of California, Santa Barbara · USSun Yat-sen University · CNSuzhou University of Science and Technology · CN

Funding

Research Supplements to Promote Diversity in Health-Related ResearchR35GM139640 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Liming Zhang · 2021 to 2026
$2.5M
Insertion Into Unactivated/Deactivated C(sp3)-H Bonds Enabled by Oxidatively Generated, Highly Reactive a-Oxo Gold Carbenes: A Safe Non-Diazo yet More Potent ApproachR01GM123342 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ZHANG, LIMING · 2017 to 2020
$1.1M
NIGMS NIH HHS R01 GM123342NIGMS NIH HHS R01GM123342NIGMS NIH HHS R35 GM139640NIGMS NIH HHS R35GM139640Postdoctoral Science Foundation of Jiangsu Province 2021M693279
6 · The paper itself

Abstract

An oxidative strategy is reported to access α-oxo BMIDA gold carbenes directly from BMIDA-terminated alkynes. Besides offering expedient access to seldom studied boryl metal carbenes, these BMIDA gold carbene species undergo facile insertions into methyl, methylene, methine, and benzylic C-H bonds in the absence of the Thorpe-Ingold effect. They also undergo efficient OH insertion, cyclopropanation, and F-C alkylations. This chemistry provides rapid access to structurally diverse α-BMIDA ketones, which are scarcely documented. In combination with DFT studies, the role of BMIDA is established to be an electron-donating group that attenuates the high electrophilicity of the gold carbene center.

Indexed as

AlkynesCarbenesC−H InsertionGold Catalysisα-Boryl Ketones

Identifiers

PMID36806835
PMCPMC10079581
OpenAlexW4321365718

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.