ArticleEuropean radiology2023
Tumour-pleura relationship on CT is a risk factor for occult lymph node metastasis in peripheral clinical stage IA solid adenocarcinoma.
Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 10 citations in OpenAlex.
- Preoperative Contrast-enhanced CT Features Associated with Occult Lymph Node Metastasis in Early-Stage Solid Non-Small Cell Lung Cancer.Radiology. Imaging cancer · 2026Article
- Prognostic factors analysis of surgical resection after conversion therapy for isolated pleural metastatic lung cancer: a retrospective analysis.Frontiers in medicine · 2026Article
- CT-based intratumoral habitat and peritumoral radiomics model to predict spread through air spaces in solid lung adenocarcinoma with diameter ≤ 2 cm: a dual-center study.Frontiers in oncology · 2026Article
- CT-based machine learning model integrating intra- and peri-tumoral radiomics features for predicting occult lymph node metastasis in peripheral lung cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Computed Tomography-Based Radiomic Nomogram to Predict Occult Pleural Metastasis in Lung Cancer.Current oncology (Toronto, Ont.) · 2025Article
- Prognostic significance of visceral pleural changes in stage IA lung adenocarcinoma: a retrospective study.Frontiers in oncology · 2025Article
- Tumour-pleura relationship on computed tomography (CT) provides effective risk stratification for peripheral pulmonary nodules with Lung Imaging Reporting and Data System (Lung-RADS) score of 4X.Quantitative imaging in medicine and surgery · 2024Article
- A nomogram predicting the risk of extrathoracic metastasis at initial diagnosis of TTranslational lung cancer research · 2024Article
- Tumor Location Is a Significant Predictor of Lymphovascular Invasion in Patients With Small-sized Non-small Cell Lung Cancer.In vivo (Athens, Greece)Article
- Risk analysis of visceral pleural invasion in malignant solitary pulmonary nodules that appear touching the pleural surface.Therapeutic advances in respiratory diseaseArticle
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate whether the tumour-pleura relationship on computed tomography (CT) is a risk factor for occult lymph node metastasis (OLNM) in peripheral clinical stage IA solid adenocarcinoma.
methodsA total of 232 patients were included in the study. The tumour-pleura relationship was divided into four types: type 1, the tumour was unrelated to the pleura; type 2, the tumour was not in contact with the pleura, and one or more linear or striated pleural tags were visible; type 3, the tumour was not in contact with the pleura, and one or more linear or striated pleural tags with soft tissue component at the pleural end were visible; and type 4, the tumour was in contact with the pleura. Univariate and multivariate logistic regression analyses were used to identify the predictive factors, including the tumour-pleura relationship, clinical factors, conventional CT findings, and pathology-reported visceral pleural invasion, for OLNM.
resultsType 3 and 4 tumour-pleura relationships were more likely to have visceral pleural invasion than type 1 and 2 tumour-pleura relationships (p < 0.001). Univariate and multivariate logistic regression analyses revealed that the type 3 or 4 tumour-pleura relationship (OR: 3.261, p = 0.026), carcinoembryonic antigen level (OR: 3.361, p = 0.006), cytokeratin 19 fragments level (OR: 2.539, p = 0.025), and mediastinal window tumour size (OR: 1.078, p = 0.020) were predictive factors for OLNM.
conclusionsThe type 3 or 4 tumour-pleura relationship is correlated with a greater risk of OLNM in peripheral clinical stage IA solid adenocarcinoma. KEY POINTS: • The tumour-pleura relationship on CT is a risk factor for occult lymph node metastasis in peripheral clinical stage IA solid adenocarcinoma. • Other risk factors for OLNM include CEA level, CYFRA level, and mediastinal window tumour size. • Pathology-reported visceral pleural invasion is not a risk factor for OLNM.
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