Evidence map›Paper›PMID 36806357›Full record

ArticleThe international journal of biochemistry & cell biology2023

From mitochondria to cells to humans: Targeting bioenergetics in aging and disease.

Brandon J Berry, Gavin A Pharaoh, David J Marcinek

Abstract read
In one paragraph

Article in The international journal of biochemistry & cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brandon J BerryUniversity of Washington Medical Center, Department of Laboratory Medicine and Pathology, 1959 NE Pacific St., Seattle, WA 98195, USA. Electronic address: bberry5@uw.edu.
Gavin A PharaohUniversity of Washington, Department of Radiology, and Institute for Stem Cell and Regenerative Medicine, South Lake Union Campus, 850 Republican St., Brotman D142, Box 358050, Seattle, WA 98109, USA. Electronic address: gpharaoh@uw.edu.
David J MarcinekUniversity of Washington Medical Center, Department of Laboratory Medicine and Pathology, 1959 NE Pacific St., Seattle, WA 98195, USA; University of Washington, Department of Radiology, and Institute for Stem Cell and Regenerative Medicine, South Lake Union Campus, 850 Republican St., Brotman D142, Box 358050, Seattle, WA 98109, USA. Electronic address: dmarc@uw.edu.

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI PRUSKY, GLEN THOMAS · 1985 to 2021
$29.6M
Biological Mechanisms of Healthy Aging Training GrantT32AG066574 · NIA · UNIVERSITY OF WASHINGTON · PI David J. Marcinek, Jessica E Young · 2020 to 2026
$5.3M
NIA NIH HHS P01 AG001751NIA NIH HHS T32 AG066574
6 · The paper itself

Abstract

In vivo control over metabolism is at the cutting edge of biomedical research. The particulars of mitochondrial function are especially important to understand in vivo to progress metabolic therapies that will be relevant for diseases of aging. Understanding the differences between how mitochondria function in vitro versus in vivo will be a necessary challenge to overcome to achieve mitochondrial medicine. In this article we outline how discoveries in invertebrate models will be informative for understanding the basic biology of mitochondria to streamline translation to mammals and eventually to humans. Further, we highlight examples of how what is known about mitochondria in vitro is translatable to in vivo models and, in some cases, to human diseases.

Indexed as

Energy MetabolismMitochondriaAgingAnimalsHumansMammalsAgingBioenergeticsMembrane potentialMetabolismProtonmotive forceRespiration

Identifiers

PMID36806357
PMCPMC10033341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.