Evidence map›Paper›PMID 36806330›Full record

ArticleeLife2023

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels.

Priscilla S-W Yeung, Megumi Yamashita, Murali Prakriya

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. ORAI CaBiomolecules · 2024
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Priscilla S-W Yeung *Department of Pharmacology, Northwestern University, Chicago, United States.ORCID 0000-0001-5400-8639
Megumi Yamashita *Department of Pharmacology, Northwestern University, Chicago, United States.ORCID 0000-0003-0196-0428
Murali PrakriyaDepartment of Pharmacology, Northwestern University, Chicago, United States.ORCID 0000-0003-0781-4480

Funding

Store-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4M
Regulation of synaptic plasticity and cognitive functions by store-operated Orai1 channelsR01NS115508 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2020 to 2022
$1.3M
Molecular Mechanisms of CRAC Channel GatingF31NS101830 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YEUNG, PRISCILLA SEE-WAI · 2017 to 2018
$82k
NIH HHS F31NS101830NIH HHS R01 NS057499NIH HHS R01 NS115508NINDS NIH HHS F31 NS101830NINDS NIH HHS R01 NS057499NINDS NIH HHS R01 NS115508
6 · The paper itself

Abstract

Ca

Indexed as

Calcium ChannelsCalcium Release Activated Calcium ChannelsGain of Function MutationHumansMutationNeoplasm ProteinsORAI1 ProteinStromal Interaction Molecule 1Calcium ChannelsCalcium Release Activated Calcium ChannelsNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1biochemistrychemical biologyCRAC channelsgatinghumaninactivationmolecular biophysicsOrai1STIM1store-operated calcium entrystructural biology

Identifiers

PMID36806330
PMCPMC9991058
OpenAlexW4321371666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.