ArticleEpilepsia2023
Critical role of the ventral temporal lobe in naming.
Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Improved naming in patients with Broca's aphasia with tDCS.Journal of neurology, neurosurgery, and psychiatry · 2024Trial
- Article
- The Extended Language Network: Language-Responsive Brain Areas Whose Contributions to Language Remain To Be Discovered.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Beyond Broca and Wernicke: Epilepsy surgery in the language areas.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- The reading brain - Transforming vision into language.Progress in neurobiology · 2026Review
- Medial Pulvinar Nucleus as a Causal Hub for Heteromodal Naming.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Frontotemporal network interactions causally support rapid concreteness judgments during reading.PLoS biology · 2026Article
- Whole-Brain Dynamic Causal Tractography Atlas of Auditory and Visual Speech Networks Derived From Intracranial Neurophysiologic Data.Neurology · 2026Observational
- The ventral visual stream for reading converges on the transmodal language network.bioRxiv : the preprint server for biology · 2025Article
- Involved but not essential: cognitive activity in periventricular nodules and neuropsychological outcomes following their ablation.Journal of neurosurgery · 2025Article
- Object naming after epilepsy surgery in the dominant left temporal lobe: risk factors, time course and long-term outcome.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Lesion and lesion network localization of dysnomia after epilepsy surgery.Brain : a journal of neurology · 2025Article
- How well can simple clinical features predict long-term language recovery after left-hemisphere glioma surgery?Journal of neuro-oncology · 2025Article
- Networks for proper versus common name retrieval: insights from causal mapping and new hypotheses.Brain communications · 2025Review
- Evaluating post-thrombectomy effective connectivity changes in anterior circulation stroke.Annals of clinical and translational neurology · 2024Article
- Dissociation of reading and naming in ventral occipitotemporal cortex.Brain : a journal of neurology · 2024Article
- Picture naming test through the prism of cognitive neuroscience and linguistics: adapting the test for cerebellar tumor survivors-or pouring new wine in old sacks?Frontiers in psychology · 2024Review
- The spatiotemporal dynamics of semantic integration in the human brain.Nature communications · 2023Article
- Subacute aphasia recovery is associated with resting-state connectivity within and beyond the language network.Annals of clinical and translational neurology · 2023Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveLexical retrieval deficits are characteristic of a variety of different neurological disorders. However, the exact substrates responsible for this are not known. We studied a large cohort of patients undergoing surgery in the dominant temporal lobe for medically intractable epilepsy (n = 95) to localize brain regions that were associated with anomia.
methodsWe performed a multivariate voxel-based lesion-symptom mapping analysis to correlate surgical lesions within the temporal lobe with changes in naming ability. Additionally, we used a surface-based mixed-effects multilevel analysis to estimate group-level broadband gamma activity during naming across a subset of patients with electrocorticographic recordings and integrated these results with lesion-deficit findings.
resultsWe observed that ventral temporal regions, centered around the middle fusiform gyrus, were significantly associated with a decline in naming. Furthermore, we found that the ventral aspect of temporal lobectomies was linearly correlated to a decline in naming, with a clinically significant decline occurring once the resection extended 6 cm from the anterior tip of the temporal lobe on the ventral surface. On electrocorticography, the majority of these cortical regions were functionally active following visual processing. These loci coincide with the sites of susceptibility artifacts during echoplanar imaging, which may explain why this region has been previously underappreciated as the locus responsible for postoperative naming deficits. SIGNIFICANCE: Taken together, these data highlight the crucial contribution of the ventral temporal cortex in naming and its important role in the pathophysiology of anomia following temporal lobe resections. As such, surgical strategies should attempt to preserve this region to mitigate postoperative language deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.