ArticleBMJ open2023
Cohort profile: the Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease (UCC-SMART) Study-an ongoing prospective cohort study of patients at high cardiovascular risk in the Netherlands.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Impact of risk factor burden and vascular bed involvement on dementia risk in individuals with established cardiovascular disease.American journal of preventive cardiology · 2026Article
- Current Evidence and Future Directions for Colchicine in the Prevention of Atherosclerotic Cardiovascular Disease.Thrombosis and haemostasis · 2026Review
- Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model.European heart journal · 2026Article
- Article
- Relation Between Adiposity Measures and the Risk of a Composite of Cardiovascular Events, Diabetes, and Cancer in Patients With Cardiovascular Disease.Clinical obesity · 2026Article
- Applicability of guideline-informing lipid-lowering clinical trials to contemporary real-world patients with atherosclerotic cardiovascular disease.European heart journal. Quality of care & clinical outcomes · 2025Article
- The relationship between the EAT-Lancet dietary pattern and risk of cardiovascular events in patients with established cardiovascular disease.European journal of nutrition · 2025Article
- DISH as a marker for incident diabetes mellitus in cardiovascular disease patients.Rheumatology (Oxford, England) · 2025Article
- Arterial stiffness and atherosclerosis and incident cardiovascular events and all-cause mortality in individuals with manifest cardiovascular disease with and without type 2 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Thoracic aortic calcifications on chest radiographs and incident major adverse limb events in cardiovascular disease patients.The international journal of cardiovascular imaging · 2025Observational
- Artificial Intelligence in Ischemic Heart Disease Prevention.Current cardiology reports · 2025Review
- Estimating the Risk of Cardiovascular Events in U.S. Veterans Using the SMART Risk Score.JACC. Advances · 2025Article
- Dietary habits and compliance with dietary guidelines in patients with established cardiovascular disease.European journal of clinical nutrition · 2024Article
- Sex differences in modifiable risk factors for stroke incidence and recurrence: the UCC-SMART study.Journal of neurology · 2024Article
- Plasma Markers of Alzheimer's Disease Pathology, Neuronal Injury, and Astrocytic Activation and MRI Load of Vascular Pathology and Neurodegeneration: The SMART-MR Study.Journal of the American Heart Association · 2024Article
- Association between lower extremity arterial calcification and coronary arterial calcification in a population at increased risk of cardiovascular disease.BMJ open diabetes research & care · 2024Article
- Article
- Risk Factors for Medial and Intimal Intracranial Internal Carotid Artery Calcification in Men and Women with Cardiovascular Disease: The UCC-SMART Study.Cerebrovascular diseases (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
26 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease (UCC-SMART) Study is an ongoing prospective single-centre cohort study with the aim to assess important determinants and the prognosis of cardiovascular disease progression. This article provides an update of the rationale, design, included patients, measurements and findings from the start in 1996 to date.
participantsThe UCC-SMART Study includes patients aged 18-90 years referred to the University Medical Center Utrecht, the Netherlands, for management of cardiovascular disease (CVD) or severe cardiovascular risk factors. Since September 1996, a total of 14 830 patients have been included. Upon inclusion, patients undergo a standardised screening programme, including questionnaires, vital signs, laboratory measurements, an ECG, vascular ultrasound of carotid arteries and aorta, ankle-brachial index and ultrasound measurements of adipose tissue, kidney size and intima-media thickness. Outcomes of interest are collected through annual questionnaires and adjudicated by an endpoint committee. FINDINGS TO DATE: By May 2022, the included patients contributed to a total follow-up time of over 134 000 person-years. During follow-up, 2259 patients suffered a vascular endpoint (including non-fatal myocardial infarction, non-fatal stroke and vascular death) and 2794 all-cause deaths, 943 incident cases of diabetes and 2139 incident cases of cancer were observed up until January 2020. The UCC-SMART cohort contributed to over 350 articles published in peer-reviewed journals, including prediction models recommended by the 2021 European Society of Cardiology CVD prevention guidelines. FUTURE PLANS: The UCC-SMART Study guarantees an infrastructure for research in patients at high cardiovascular risk. The cohort will continue to include about 600 patients yearly and follow-up will be ongoing to ensure an up-to-date cohort in accordance with current healthcare and scientific knowledge. In the near future, UCC-SMART will be enriched by echocardiography, and a food frequency questionnaire at baseline enabling the assessment of associations between nutrition and CVD and diabetes.
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Registered trials
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