Evidence map›Paper›PMID 36806122›Full record

ArticleClinical endocrinology2023

Association of GDF15 levels with body mass index and endocrine status in β-thalassaemia.

Yanislava Karusheva, Clive J Petry, Nirmani Yasara, Dulani Kottahachchi, Anuja Premawardhena, Peter Barker, Keith Burling, Naveed Sattar, Paul Welsh, Sachith Mettananda and 1 more

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In one paragraph

Article in Clinical endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Yanislava KarushevaMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4000-7894
Clive J PetryMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Nirmani YasaraDepartment of Paediatrics, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Dulani KottahachchiDepartment of Physiology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Anuja PremawardhenaColombo North Teaching Hospital, Ragama, Sri Lanka.
Peter BarkerNIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Keith BurlingNIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Naveed SattarUniversity of Glasgow, School of Cardiovascular and Metabolic Health, Glasgow, UK.
Paul WelshUniversity of Glasgow, School of Cardiovascular and Metabolic Health, Glasgow, UK.
Sachith MettanandaDepartment of Paediatrics, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Stephen O'RahillyMRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
University of Kelaniya · LKUniversity of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GBUniversity of Glasgow · GB

Funding

Department of Health BRC-1215-20014Medical Research Council MC_UU_00014/1Medical Research Council MC.UU.00014.5Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/1
6 · The paper itself

Abstract

objectiveGDF15 has emerged as a stress-induced hormone, acting on the brain to reduce food intake and body weight while affecting neuroendocrine function. Very high GDF15 levels are found in thalassaemia, where growth, energy balance and neuroendocrine function are impaired. We examined the relationships between GDF15 and anthropometric measures and endocrine status in β-thalassaemia.

designCross sectional study. PATIENTS: All β-thalassaemia patients attending the thalassaemia unit of Colombo North Teaching Hospital for blood transfusions. MEASUREMENTS: Anthropometric data, appetite scores, circulating GDF15, IGF, thyroid and reproductive hormone levels in 103 β-thalassaemia patients were obtained.

resultsGDF15 levels were markedly elevated in thalassaemia patients (24.2-fold with β-thalassaemia major compared with healthy controls). Among patients with β-thalassaemia major, the relationship between GDF15 and body mass index (BMI) was curvilinear with all individuals with GDF15 levels above 24,000 pg/mL having a BMI below 20 kg/m

conclusionsGDF15 levels were markedly elevated in patients with β-thalassaemia and its association with BMI is consistent with the known effect of GDF15 to reduce body weight. The inverse association between GDF15 with IGF1 levels may reflect a neuroendocrine impact of GDF15 or an indirect effect via impaired nutritional state. The positive association with testosterone in males and gonadotropins in both sexes, was surprising and should prompt further GDF15 studies on the hypothalamic pituitary gonadal axis.

Indexed as

beta-ThalassemiaBody Mass IndexBody WeightCross-Sectional StudiesFemaleGonadotropinsGrowth Differentiation Factor 15HumansMaleTestosteroneGDF15 protein, humanGonadotropinsGrowth Differentiation Factor 15Testosteronebeta-thalassaemiabody mass indexGDF15IGF 1

Identifiers

PMID36806122
PMCPMC10952638
OpenAlexW4321446223

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.