Evidence map›Paper›PMID 36805869›Full record

ArticleNuclear medicine and biology

Theranostic cobalt-55/58m for neurotensin receptor-mediated radiotherapy in vivo: A pilot study with dosimetry.

Wilson Lin, Eduardo Aluicio-Sarduy, Hailey A Houson, Todd E Barnhart, Volkan Tekin, Justin J Jeffery, Ashley M Weichmann, Kendall E Barrett, Suzanne E Lapi, Jonathan W Engle

Open access · greenAbstract read
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Evaluation ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  5. Review
  6. Controlling the Redox Chemistry of Cobalt Radiopharmaceuticals.Angewandte Chemie (International ed. in English) · 2024
    Article
  7. Synthesis ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  8. Article
  9. Preclinical evaluation of [Scientific reports · 2023
    Article
  10. Separation of cyclotron-produced cobalt-55/58m from iron targets using cation exchange chromatography with non-aqueous solvents and extraction chromatography.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wilson LinDepartment of Medical Physics, University of Wisconsin, 1111 Highland Ave., Madison, WI 53705, United States. Electronic address: wlin99@wisc.edu.
Eduardo Aluicio-SarduyDepartment of Medical Physics, University of Wisconsin, 1111 Highland Ave., Madison, WI 53705, United States.
Hailey A HousonDepartment of Radiology, University of Alabama at Birmingham, 1824 6th Ave South, Birmingham, AL 35294, United States.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin, 1111 Highland Ave., Madison, WI 53705, United States.
Volkan TekinDepartment of Radiology, University of Alabama at Birmingham, 1824 6th Ave South, Birmingham, AL 35294, United States.
Justin J JefferyUniversity of Wisconsin Carbone Cancer Center, Madison, WI 53705, United States.
Ashley M WeichmannUniversity of Wisconsin Carbone Cancer Center, Madison, WI 53705, United States.
Kendall E BarrettDepartment of Medical Physics, University of Wisconsin, 1111 Highland Ave., Madison, WI 53705, United States.
Suzanne E LapiDepartment of Radiology, University of Alabama at Birmingham, 1824 6th Ave South, Birmingham, AL 35294, United States.
Jonathan W EngleDepartment of Medical Physics, University of Wisconsin, 1111 Highland Ave., Madison, WI 53705, United States; Department of Radiology, University of Wisconsin, 600 Highland Ave., Madison, WI 53792, United States.
University of Wisconsin–Madison · USUniversity of Alabama at Birmingham · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Radionuclide Production and Radiochemistry Core Description CoreP01CA250972 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BEDNARZ, BRYAN PATRICK · 2020 to 2024
$12.5M
NCI NIH HHS P01 CA250972NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

Neurotensin receptor 1 (NTSR1) can stimulate tumor proliferation through neurotensin (NTS) activation and are overexpressed by a variety of cancers. The high binding affinity of NTS/NTSR1 makes radiolabeled NTS derivatives interesting for cancer diagnosis and staging. Internalization of NTS/NTSR1 also suggests therapeutic application with high LET alpha particles and low energy electrons. We investigated the therapeutic efficacy of [

methodsTargeting properties and cytotoxicity of [

resultsHPLC measured radiochemical purity of [

conclusionThe enhanced in vitro cytotoxicity and high tumor-to-background led us to investigate the therapeutic efficacy of [

Indexed as

Precision MedicineReceptors, NeurotensinAnimalsCobalt RadioisotopesFemaleHumansMiceMice, NudeNeurotensinPilot ProjectsCobalt-55Cobalt RadioisotopesNeurotensinReceptors, NeurotensinAuger electronCobalt-55/58mNeurotensinTargeted radionuclide therapyTheranostic

Identifiers

PMID36805869
PMCPMC10121947
OpenAlexW4320487010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.