Evidence map›Paper›PMID 36805807›Full record

ArticleeLife2023

Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord.

Yuka Nakamura, Miyuki Kurabe, Mami Matsumoto, Tokiharu Sato, Satoshi Miyashita, Kana Hoshina, Yoshinori Kamiya, Kazuki Tainaka, Hitoshi Matsuzawa, Nobuhiko Ohno and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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  12. Spinal cord morphology and PKD2L1Frontiers in neuroanatomy · 2025
    Article
  13. GABAmicroPublication biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yuka NakamuraDepartment of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Japan.
Miyuki KurabeDivision of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.ORCID https://orcid.org/0000-0003-1804-7037
Mami MatsumotoSection of Electron Microscopy, Supportive Center for Brain Research, National Institute for Physiological Sciences, Okazaki, Japan.
Tokiharu SatoDepartment of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Japan.
Satoshi MiyashitaDepartment of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Japan.
Kana HoshinaDepartment of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Japan.
Yoshinori KamiyaDivision of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.ORCID https://orcid.org/0000-0001-9790-9867
Kazuki TainakaDepartment of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Japan.
Hitoshi MatsuzawaCenter for Advanced Medicine and Clinical Research, Kashiwaba Neurosurgical Hospital, Sapporo, Japan.
Nobuhiko OhnoDepartment of Anatomy, Division of Histology and Cell Biology, Jichi Medical University, School of Medicine, Shimotsuke, Japan.
Masaki UenoDepartment of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Japan.ORCID https://orcid.org/0000-0003-1484-9921
Niigata University · JPJichi Medical University · JPNagoya City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebrospinal fluid-contacting neurons (CSF-cNs) are enigmatic mechano- or chemosensory cells lying along the central canal of the spinal cord. Recent studies in zebrafish larvae and lampreys have shown that CSF-cNs control postures and movements via spinal connections. However, the structures, connectivity, and functions in mammals remain largely unknown. Here we developed a method to genetically target mouse CSF-cNs that highlighted structural connections and functions. We first found that intracerebroventricular injection of adeno-associated virus with a neuron-specific promoter and

Indexed as

LocomotionZebrafishAnimalsCalcium ChannelsInterneuronsMammalsMiceMotor NeuronsNeurons, EfferentReceptors, Cell SurfaceCalcium ChannelsPkd2l1 protein, mouseReceptors, Cell Surfacecerebrospinal fluid-contacting neuronlocomotionmouseneural circuitneurosciencespinal cord

Identifiers

PMID36805807
PMCPMC9943067
OpenAlexW4321366513

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.