ArticleDiabetologia2023
Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study.
Article in Diabetologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Prevalence of sarcopenic obesity in adult patients with diabetes and associated factors: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review.Acta diabetologica · 2025Pooled it
- Body composition displays expected and unexpected contributions to blood pressure and glycemia in young South African women.BMJ open diabetes research & care · 2026Article
- Sofrito and Fruit Consumption Associated with Lower Risk of Type 2 Diabetes in an Urban Latin American Cohort.Nutrients · 2026Article
- Refining visceral adipose tissue quantification: Influence of sex, age, and BMI on single slice estimation in 3D MRI of the German National Cohort.Zeitschrift fur medizinische Physik · 2026Article
- Prediabetes Phenotypes and Adiposity Patterns: Findings From a Population-Based Study.Journal of diabetes research · 2026Article
- Sex-specific protective role of lower-body fat in type 2 diabetes: mediation through insulin resistance in a BMI-matched population.BMJ open diabetes research & care · 2025Article
- Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood.Maternal & child nutrition · 2025Article
- Association of Serum Uric Acid Levels with Cardiometabolic Factors in Adolescents with Obesity: A Cross-Sectional Study.Metabolites · 2025Article
- Article
- Prevention of cardiovascular disease in women with type 2 diabetes: the role of incretin mimetics and sodium-glucose cotransporter-2 inhibitors.American journal of physiology. Cell physiology · 2025Review
- Sex differences in ectopic lipid deposits and cardiac function across a wide range of glycemic control: a secondary analysis.Obesity (Silver Spring, Md.) · 2024Article
- Do poor psychosocial resources mediate health inequalities in type 2 diabetes mellitus? Findings from the Maastricht study.European journal of public health · 2024Article
- Article
- Sex differences in pathogenesis and treatment of dyslipidemia in patients with type 2 diabetes and steatotic liver disease.Frontiers in medicine · 2024Review
- Association of the hemoglobin glycation index with cardiovascular and all-cause mortality in individuals with hypertension: findings from NHANES 1999-2018.Frontiers in endocrinology · 2024Article
- Prognostic Value of Computed Tomography-Measured Visceral Adipose Tissue in Patients with Pulmonary Infection Caused by Carbapenem-ResistantInfection and drug resistance · 2024Article
- Further investigation of the association between diabetes status and body composition and whether this association is moderated by sex.Diabetologia · 2023Article
- Further investigation of the association between diabetes status and body composition and whether this association is moderated by sex. Reply to Mai Y [letter].Diabetologia · 2023Article
- Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.Cardiovascular diabetology · 2023Article
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
aims/hypothesisObesity is a major risk factor for type 2 diabetes. However, body composition differs between women and men. In this study we investigate the association between diabetes status and body composition and whether this association is moderated by sex.
methodsIn a population-based cohort study (n=7639; age 40-75 years, 50% women, 25% type 2 diabetes), we estimated the sex-specific associations, and differences therein, of prediabetes (i.e. impaired fasting glucose and/or impaired glucose tolerance) and type 2 diabetes (reference: normal glucose metabolism [NGM]) with dual-energy x-ray absorptiometry (DEXA)- and MRI-derived measures of body composition and with hip circumference. Sex differences were analysed using adjusted regression models with interaction terms of sex-by-diabetes status.
resultsCompared with their NGM counterparts, both women and men with prediabetes and type 2 diabetes had more fat and lean mass and a greater hip circumference. The differences in subcutaneous adipose tissue, hip circumference and total and peripheral lean mass between type 2 diabetes and NGM were greater in women than men (women minus men [W-M] mean difference [95% CI]: 15.0 cm CONCLUSIONS/
interpretationThis study indicates that there are sex differences in body composition associated with type 2 diabetes. The pathophysiological significance of these sex-associated differences requires further study.
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