ArticleThe Journal of experimental biology2023
Estradiol regulates voltage-gated potassium currents in corticotropin-releasing hormone neurons.
Article in The Journal of experimental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Electrophysiological characterization of neuropeptide S-expressing neurons in the periLC: influence of the female estrous cycle on neuronal excitability in mice.Pflugers Archiv : European journal of physiology · 2026Article
- Electrophysiological comparison of left versus right stellate ganglia neurons.Journal of molecular and cellular cardiology plus · 2025Article
- Development and prenatal exposure to androgens alter potassium currents in gonadotropin-releasing hormone neurons from female mice.Journal of neuroendocrinology · 2024Article
- Sex differences in pituitary corticotroph excitability.Frontiers in physiology · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Corticotropin-releasing hormone (CRH) neurons are the primary neural population controlling the hypothalamic-pituitary-adrenal (HPA) axis and the secretion of adrenal stress hormones. Previous work has demonstrated that stress hormone secretion can be regulated by circulating levels of estradiol. However, the effect of estradiol on CRH neuron excitability is less clear. Here, we show that chronic estradiol replacement following ovariectomy increases two types of potassium channel currents in CRH neurons: fast inactivating voltage-gated A-type K+ channel currents (IA) and non-inactivating M-type K+ channel currents (IM). Despite the increase in K+ currents following estradiol replacement, there was no overall change in CRH neuron spiking excitability assessed with either frequency-current curves or current ramps. Together, these data reveal a complex picture whereby ovariectomy and estradiol replacement differentially modulate distinct aspects of CRH neuron and HPA axis function.
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