ArticleDiabetology & metabolic syndrome2023
Atherosclerosis indexes and incident T2DM in middle-aged and older adults: evidence from a cohort study.
Article in Diabetology & metabolic syndrome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
- Triglyceride-glucose index and systemic immune-inflammation index are associated with left ventricular hypertrophy in type 2 diabetes mellitus patients.BMC endocrine disorders · 2026Article
- The association of nontraditional lipid parameters with all-cause and cardiovascular mortality: A national cohort study.Medicine · 2026Article
- Prognostic value of the atherogenic index of plasma in patients with multivessel coronary disease undergoing CABG: a retrospective cohort study.Lipids in health and disease · 2026Article
- Association between non-traditional lipid-inflammatory parameters and incident diabetes: a national prospective cohort study.BMC endocrine disorders · 2026Article
- Impact of Dietary Interventions withFoods (Basel, Switzerland) · 2026Article
- Global Trends in Research of Intestinal Cells and Type 2 Diabetes Mellitus: A Bibliometric and Visualized Analysis from 2004 to 2023.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Traditional Chinese medicine acupoint pasting for preventing and treating gastrointestinal reactions in type II diabetes mellitus patients undergoing glucagon-like peptide-1 receptor agonist therapy: A clinical study.Journal of medical biochemistry · 2025Article
- A J-shaped association between the atherogenic index of plasma and diabetes risk in a Japanese population: a large-scale retrospective cohort study.BMC endocrine disorders · 2025Article
- Joint assessment of abdominal obesity and non-traditional lipid parameters for primary prevention of cardiometabolic multimorbidity: insights from the China health and retirement longitudinal study 2011-2018.Cardiovascular diabetology · 2025Article
- Gender-specific association between a novel atherogenic index of plasma, metabolic parameters and inflammation among obese adults.BMC endocrine disorders · 2025Article
- Association between hemoglobin glycation index and the risk of cardiovascular disease in early-stage cardiovascular-kidney-metabolic syndrome: evidence from the China health and retirement longitudinal study.Frontiers in endocrinology · 2025Article
- Association Between the Waist-Triglyceride Index and Incident Type 2 Diabetes in the Elderly: A Retrospective Cohort Study.Journal of diabetes research · 2025Article
- Association between atherogenic index of plasma and gestational diabetes mellitus: a prospective cohort study based on the Korean population.Cardiovascular diabetology · 2024Article
- Gender differences in the association between changes in the atherogenic index of plasma and cardiometabolic diseases: a cohort study.Lipids in health and disease · 2024Article
- Evaluation of the role of atherogenic index of plasma in the reversion from Prediabetes to normoglycemia or progression to Diabetes: a multi-center retrospective cohort study.Cardiovascular diabetology · 2024Article
- Article
- Obesity- and lipid-related indices as a predictor of type 2 diabetes in a national cohort study.Frontiers in endocrinology · 2023Article
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8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundType 2 diabetes mellitus (T2DM) is an expanding global health problem, requiring effective methods for predicting and diagnosing in its early stages of development. Previous studies reported the prognostic value of the atherosclerosis indexes in both cardiovascular diseases and T2DM. However, the predictive performance of Non-HDL-C, AI, AIP, TG/HDL-C and LCI indexes on the risk of T2DM remains unclear. This study aims to compare the five atherosclerosis indexes for predicting T2DM in middle-aged and elderly Chinese.
methodsData are collected from wave 2011 and wave 2015 of China Health and Retirement Longitudinal Study (CHARLS). Multi-variate logistic regression models were used to estimate odds ratio (OR) with 95% confidence interval (CI) of incident T2DM with five atherosclerosis indexes, and the restricted cubic splines were used to visualize the dose-response relationships. Receiver operating characteristic (ROC) curve was drawn and the areas under the curve (AUC) were used to compare the performance of the five atherosclerosis indexes in predicting T2DM.
resultsA total of 504 (10.97%) participants had T2DM. Multi-variate logistic regression analysis showed that five atherosclerosis indexes were associated with T2DM, with adjusted ORs (95% CIs) of 1.29 (1.15-1.45), 1.29 (1.18-1.42), 1.45 (1.29-1.62), 1.41 (1.25-1.59) and 1.34 (1.23-1.48) for each IQR increment in Non-HDL-C, TG/HDLC, AI, AIP and LCI, respectively. Restricted cubic spline regression showed a nonlinear correlation between five atherosclerosis indexes and the risk of T2DM (p for nonlinear < 0.001). According to the ROC curve analysis, LCI had the highest AUC (0.587 [0.574-0.600]).
conclusionWe found that LCI, compared with other indexes, was a better predictor in the clinical setting for identifying individuals with T2DM in middle-aged and elderly Chinese. LCI monitoring might help in the early identification of individuals at high risk of T2DM.
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