Evidence map›Paper›PMID 36805435›Full record

Trial reportNeurology2023

Respiratory Strength Training in Amyotrophic Lateral Sclerosis: A Double-Blind, Randomized, Multicenter, Sham-Controlled Trial.

Emily K Plowman, Lauren T Gray, Jennifer Chapin, Amber Anderson, Terrie Vasilopoulos, Clifton Gooch, Tuan Vu, James P Wymer

Registry-linked trialOpen access · greenAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07606235 (Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07606235 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS

TypeinterventionalSponsorNova Southeastern UniversityRan2026 to 2026Enrolled5ConditionsAmyotrophic Lateral Sclerosis (ALS), Dysphagia, DystussiaArmsTranscutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Emily K PlowmanFrom the Aerodigestive Research Core (E.K.P., L.T.G., J.C., A.A.), and Departments of Speech, Language, and Hearing Sciences (E.K.P.), Neurology (E.K.P., J.P.W.), Surgery (E.K.P.), and Anesthesiology (T.V.), University of Florida, Gainesville; Center for Collaborative Research (L.T.G.), NOVA Southeastern University, Fort Lauderdale; and Department of Neurology (C.G., T.V.), University of South Florida, Tampa. eplowman@phhp.ufl.edu.
Lauren T GrayFrom the Aerodigestive Research Core (E.K.P., L.T.G., J.C., A.A.), and Departments of Speech, Language, and Hearing Sciences (E.K.P.), Neurology (E.K.P., J.P.W.), Surgery (E.K.P.), and Anesthesiology (T.V.), University of Florida, Gainesville; Center for Collaborative Research (L.T.G.), NOVA Southeastern University, Fort Lauderdale; and Department of Neurology (C.G., T.V.), University of South Florida, Tampa.
Jennifer ChapinFrom the Aerodigestive Research Core (E.K.P., L.T.G., J.C., A.A.), and Departments of Speech, Language, and Hearing Sciences (E.K.P.), Neurology (E.K.P., J.P.W.), Surgery (E.K.P.), and Anesthesiology (T.V.), University of Florida, Gainesville; Center for Collaborative Research (L.T.G.), NOVA Southeastern University, Fort Lauderdale; and Department of Neurology (C.G., T.V.), University of South Florida, Tampa.ORCID 0000-0001-7326-8620
Amber AndersonFrom the Aerodigestive Research Core (E.K.P., L.T.G., J.C., A.A.), and Departments of Speech, Language, and Hearing Sciences (E.K.P.), Neurology (E.K.P., J.P.W.), Surgery (E.K.P.), and Anesthesiology (T.V.), University of Florida, Gainesville; Center for Collaborative Research (L.T.G.), NOVA Southeastern University, Fort Lauderdale; and Department of Neurology (C.G., T.V.), University of South Florida, Tampa.
Terrie VasilopoulosFrom the Aerodigestive Research Core (E.K.P., L.T.G., J.C., A.A.), and Departments of Speech, Language, and Hearing Sciences (E.K.P.), Neurology (E.K.P., J.P.W.), Surgery (E.K.P.), and Anesthesiology (T.V.), University of Florida, Gainesville; Center for Collaborative Research (L.T.G.), NOVA Southeastern University, Fort Lauderdale; and Department of Neurology (C.G., T.V.), University of South Florida, Tampa.
Clifton GoochFrom the Aerodigestive Research Core (E.K.P., L.T.G., J.C., A.A.), and Departments of Speech, Language, and Hearing Sciences (E.K.P.), Neurology (E.K.P., J.P.W.), Surgery (E.K.P.), and Anesthesiology (T.V.), University of Florida, Gainesville; Center for Collaborative Research (L.T.G.), NOVA Southeastern University, Fort Lauderdale; and Department of Neurology (C.G., T.V.), University of South Florida, Tampa.
Tuan VuFrom the Aerodigestive Research Core (E.K.P., L.T.G., J.C., A.A.), and Departments of Speech, Language, and Hearing Sciences (E.K.P.), Neurology (E.K.P., J.P.W.), Surgery (E.K.P.), and Anesthesiology (T.V.), University of Florida, Gainesville; Center for Collaborative Research (L.T.G.), NOVA Southeastern University, Fort Lauderdale; and Department of Neurology (C.G., T.V.), University of South Florida, Tampa.
James P WymerFrom the Aerodigestive Research Core (E.K.P., L.T.G., J.C., A.A.), and Departments of Speech, Language, and Hearing Sciences (E.K.P.), Neurology (E.K.P., J.P.W.), Surgery (E.K.P.), and Anesthesiology (T.V.), University of Florida, Gainesville; Center for Collaborative Research (L.T.G.), NOVA Southeastern University, Fort Lauderdale; and Department of Neurology (C.G., T.V.), University of South Florida, Tampa.ORCID 0000-0003-0809-2977
Nova Southeastern University · US

Funding

Landis Outstanding Mentor Award SupplementR01NS100859 · NINDS · UNIVERSITY OF FLORIDA · PI PLOWMAN, EMILY KATE · 2017 to 2021
$2.0M
Effects of Strength Training on Bulbar Function in Amyotrophic Lateral SclerosisR21HD075327 · NICHD · UNIVERSITY OF SOUTH FLORIDA · PI RICHTER, JOEL E · 2013 to 2014
$396k
NICHD NIH HHS R21 HD075327NINDS NIH HHS R01 NS100859
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe objective of this study was to evaluate the short-term physiologic effect and one-year functional effect of a 12-week inspiratory and expiratory respiratory strength training (RST) program in individuals with amyotrophic lateral sclerosis (ALS).

methodsA double-blinded, randomized, sham-controlled trial was conducted in 45 individuals with early-stage ALS. Participants were randomized into 12 weeks of active RST (30% load, n = 23) or sham RST (0% load, n = 22). An intent-to-treat analysis was conducted. Linear regression of pre-post change with group status and pretest scores as predictors was conducted. Primary outcomes included maximum expiratory and inspiratory pressure (MEP, MIP), and secondary outcomes were cough spirometry and forced vital capacity. Exploratory follow-up outcomes included one-year global and bulbar decline (ALS Functional Rating Scale-Revised [ALSFRS-R] total and bulbar subscale slope), oral intake status, and time to noninvasive ventilation (NIV).

resultsTheRST completion rate was 91% with no RST-related adverse events. A 12-week RST program led to increases in MEP ( DISCUSSION: RST was well tolerated and led to improvements in some, but not all, short and long-term outcomes. RST represents a proactive rehabilitative intervention that could increase physiologic capacity of specific breathing and airway clearance functions during the early stages of ALS. Further work is needed to determine optimal training intensity, resistance load specifications, and potential long-term functional outcomes. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that a mild-intensity respiratory strength training program improves maximum expiratory pressure, but not maximum inspiratory pressure, in patients with early-stage ALS.

Indexed as

Amyotrophic Lateral SclerosisResistance TrainingCoughHumansLungRespiration

Identifiers

PMID36805435
PMCPMC10103108
OpenAlexW4321366941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.