Evidence map›Paper›PMID 36804647›Full record

ArticleNature neuroscience2023

A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans.

Uros Topalovic, Sam Barclay, Chenkai Ling, Ahmed Alzuhair, Wenhao Yu, Vahagn Hokhikyan, Hariprasad Chandrakumar, Dejan Rozgic, Wenlong Jiang, Sina Basir-Kazeruni and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Neural Bases of Collective Social Behavior and Group Interactions across Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  14. Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Uros TopalovicDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4005-7979
Sam BarclayDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Chenkai LingDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Ahmed AlzuhairDepartment of Electrical Engineering, King Saud University, Riyadh, Saudi Arabia.ORCID http://orcid.org/0000-0001-6244-4852
Wenhao YuDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Vahagn HokhikyanDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2069-7290
Hariprasad ChandrakumarDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-0758-5534
Dejan RozgicDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Wenlong JiangDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Sina Basir-KazeruniDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Sabrina L MaozDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2021-4316
Cory S InmanDepartment of Psychology, University of Utah, Salt Lake City, UT, USA.
Matthias StanglDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3331-0510
Jay GillDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Ausaf BariDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Aria FallahDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Dawn EliashivDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Nader PouratianDepartment of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Itzhak FriedDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Nanthia SuthanaDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. nanthia@ucla.edu.ORCID http://orcid.org/0000-0002-8796-3277
Dejan MarkovicDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA. dejan@ucla.edu.ORCID http://orcid.org/0000-0002-6744-7531
University of California, Los Angeles · USKing Saud University · SASouthwestern Medical Center · USUniversity of Utah · US

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Mechanisms of Memory Enhancement by Deep Brain Stimulation in HumansR01NS084017 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FRIED, ITZHAK · 2013 to 2022
$4.7M
Neurostimulation and Recording of Real World Spatial Navigation in HumansU01NS103802 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUTHANA, NANTHIA A · 2017 to 2019
$3.4M
Causal mapping of emotion networks with concurrent electrical stimulation and fMRIU01NS103780 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ADOLPHS, RALPH, HOWARD, MATTHEW A. · 2018 to 2020
$2.9M
Neural Mechanisms of Spatial Representations Beyond the SelfR00NS126715 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Matthias Stangl · 2024 to 2026
$665k
Neural mechanisms of spatial representations beyond the selfK99NS126715 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STANGL, MATTHIAS · 2022 to 2023
$232k
Context-based neural representations of space: hippocampal-entorhinal neurophysiology in ambulating humansF30MH125534 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAOZ, SABRINA LEAH LEVY · 2021 to 2024
$181k
NIGMS NIH HHS T32 GM008042NIMH NIH HHS F30 MH125534NINDS NIH HHS K99 NS126715NINDS NIH HHS R00 NS126715NINDS NIH HHS R01 NS084017NINDS NIH HHS U01 NS103780NINDS NIH HHS U01 NS103802U.S. Department of Health & Human Services | National Institutes of Health (NIH) F30MH125534U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS084017U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS103780U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS103802
6 · The paper itself

Abstract

Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.

Indexed as

Deep Brain StimulationMental DisordersWearable Electronic DevicesHumans

Identifiers

PMID36804647
PMCPMC9991917
OpenAlexW4321369614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.