Evidence map›Paper›PMID 36804589›Full record

ArticleOsteoarthritis and cartilage2023

Biomarkers and longitudinal changes in lumbar spine degeneration and low back pain: the Johnston County Osteoarthritis Project.

A P Goode, R J Cleveland, V B Kraus, K A Taylor, S Z George, T A Schwartz, J Renner, J L Huebner, J M Jordan, Y M Golightly

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Association between metabolism and low back pain: a cross-sectional study.Journal of orthopaedic surgery and research · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

A P GoodeDepartment of Orthopedic Surgery, Duke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Duke University, Durham, NC, USA; Department of Population Health Sciences, Duke University, Durham, NC, USA. Electronic address: adam.goode@duke.edu.
R J ClevelandThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: becki@unc.edu.
V B KrausDepartment of Orthopedic Surgery, Duke University School of Medicine, Durham, NC, USA; Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA; Duke Department of Medicine, Duke University, NC, USA. Electronic address: kraus004@duke.edu.
K A TaylorDepartment of Orthopedic Surgery, Duke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Duke University, Durham, NC, USA. Electronic address: kenneth.taylor@duke.edu.
S Z GeorgeDepartment of Orthopedic Surgery, Duke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Duke University, Durham, NC, USA. Electronic address: steven.george@duke.edu.
T A SchwartzThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. Electronic address: tschwart@email.unc.edu.
J RennerThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Department of Radiology, University of North Carolina, Chapel Hill, NC, USA. Electronic address: jordan_renner@med.unc.edu.
J L HuebnerDuke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA. Electronic address: jhuebner@duke.edu.
J M JordanThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA; Department of Orthopedics, University of North Carolina, Chapel Hill, NC, USA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. Electronic address: joanne_jordan@med.unc.edu.
Y M GolightlyThurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA; College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: golight@email.unc.edu.
Duke University · USUniversity of North Carolina at Chapel Hill · US

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1M
Project 3P60AR049465 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JORDAN, JOANNE M. · 2003 to 2008
$6.0M
Biomarkers to Advance Clinical Phenotypes of Low Back Pain (BACk)R01AR071440 · NIAMS · DUKE UNIVERSITY · PI Adam Goode · 2017 to 2026
$5.0M
Mechanical Biomarkers of Chronic Low Back PainR01AR075399 · NIAMS · DUKE UNIVERSITY · PI Louis E. DeFrate, Adam Goode · 2019 to 2026
$3.7M
Women's knee motion patterns in functional activitiesP60AR030701 · NIAMS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI CALLAHAN, LEIGH FLEMING · 1986 to 2001
$1.9M
Mentoring in Musculoskeletal Pain PhenotypesK24AR079594 · NIAMS · DUKE UNIVERSITY · PI Adam Goode · 2022 to 2026
$927k
NIAMS NIH HHS K24 AR079594NIAMS NIH HHS L30 AR057661NIAMS NIH HHS P30 AR072580NIAMS NIH HHS P60 AR030701NIAMS NIH HHS P60 AR049465NIAMS NIH HHS R01 AR071440NIAMS NIH HHS R01 AR075399NIA NIH HHS P30 AG028716
6 · The paper itself

Abstract

objectiveTo determine if baseline biomarkers are associated with longitudinal changes in the worsening of disc space narrowing (DSN), vertebral osteophytes (OST), and low back pain (LBP).

designPaired baseline (2003-2004) and follow-up (2006-2010) lumbar spine radiographs from the Johnston County Osteoarthritis Project were graded for severity of DSN and OST. LBP severity was self-reported. Concentrations of analytes (cytokines, proteoglycans, and neuropeptides) were quantified by immunoassay. Pressure-pain threshold (PPT), a marker of sensitivity to pressure pain, was measured with a standard dolorimeter. Binary logistic regression models were used to estimate odd ratios (OR) and 95% confidence intervals (CI) of biomarker levels with DSN, OST, or LBP. Interactions were tested between biomarker levels and the number of affected lumbar spine levels or LBP.

resultsWe included participants (n = 723) with biospecimens, PPT, and paired lumbar spine radiographic data. Baseline Lumican, a proteoglycan reflective of extracellular matrix changes, was associated with longitudinal changes in DSN worsening (OR = 3.19 [95% CI 1.22, 8.01]). Baseline brain-derived neuropathic factor, a neuropeptide, (OR = 1.80 [95% CI 1.03, 3.16]) was associated with longitudinal changes in OST worsening, which may reflect osteoclast genesis. Baseline hyaluronic acid (OR = 1.31 [95% CI 1.01, 1.71]), indicative of systemic inflammation, and PPT (OR = 1.56 [95% CI 1.02, 2.31]) were associated with longitudinal increases in LBP severity.

conclusionThese findings suggest that baseline biomarkers are associated with longitudinal changes occurring in structures of the lumbar spine (DSN vs OST). Markers of inflammation and perceived pressure pain sensitivity were associated with longitudinal worsening of LBP.

Indexed as

Intervertebral Disc DegenerationLow Back PainOsteoarthritisOsteoarthritis, SpineOsteophyteBiomarkersHumansInflammationLumbar VertebraeBiomarkersBiomarkersCohort studyIntervertebral disc degenerationLow back painSpine degeneration

Identifiers

PMID36804589
PMCPMC10200763
OpenAlexW4321349172

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.