ReviewMucosal immunology2023
Necrotizing enterocolitis in premature infants-A defect in the brakes? Evidence from clinical and animal studies.
Review in Mucosal immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 26 citations in OpenAlex.
- Sepsis in neonates with necrotizing enterocolitis: outcomes and predictive model.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Diagnosis and Staging of Necrotizing Enterocolitis: Current Controversies and a Phenotype-Based Framework.Children (Basel, Switzerland) · 2026Review
- Necrotizing enterocolitis.Nature reviews. Disease primers · 2026Review
- Protective effects of enteral acetate supplementation against brain injury in a rat model of necrotizing enterocolitis.Pediatric research · 2026Article
- Temporal mapping of epithelial vs. immune cell inflammatory shifts in the neonatal intestinal mucosa.Pediatric research · 2026Article
- Pathogenesis of necrotizing enterocolitis: mechanisms and mediators.World journal of pediatric surgery · 2026Review
- Autoinflammation with infantile enterocolitis induced by a heterozygous variant (c.1357C > T) in the NLRC4 gene: a case report.Frontiers in pediatrics · 2026Article
- Bedside Utilization of Intestinal Pathology in Preterm Infants with Surgical Necrotizing Enterocolitis.American journal of perinatology · 2025Review
- Microbes, metabolites, and inflammation: mapping the early neonatal intestinal landscape.Pediatric research · 2025Article
- Rare and Intermediate Taxa Shape the Gut Bacterial Structure in Neonates and Preterm Infants with Necrotizing Enterocolitis.Journal of microbiology and biotechnology · 2025Article
- Incidence of probiotic sepsis and morbidity risk in premature infants: a meta-analysis.Pediatric research · 2025Article
- The conundrum of intestinal injury in preterm infants receiving mother's own milk.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Article
- Recent advances in understanding pathophysiology of non-nutritional stunting in very preterm infants.Clinical and experimental pediatrics · 2025Article
- Vitamin A enhances PI3K/Akt signaling and mitigates enterocyte apoptosis in a mouse model of necrotizing enterocolitis.Pediatric surgery international · 2025Article
- Guardian of the gut: butyrate-regulated FUT2 protects against experimental NEC.Pediatric research · 2025Article
- Translating regenerative medicine therapies in neonatal necrotizing enterocolitis.Pediatric research · 2024Article
- Different infant formulas can activate toll-like receptor 9 in vitro and inhibit interleukin 6 in human primary intestinal epithelial cells.European journal of nutrition · 2024Article
- Impact of Clinical Use of Probiotics on Preterm-Related Outcomes in Infants with Extremely Low Birth Weight.Nutrients · 2024Article
- Gut microbiota differences in five-year-old children that were born preterm with a history of necrotizing enterocolitis: A pilot trial.iScience · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A key aspect of postnatal intestinal adaptation is the establishment of symbiotic relationships with co-evolved gut microbiota. Necrotizing enterocolitis (NEC) is the most severe disease arising from failure in postnatal gut adaptation in premature infants. Although pathological activation of intestinal Toll-like receptors (TLRs) is believed to underpin NEC pathogenesis, the mechanisms are incompletely understood. We postulate that unregulated aberrant TLR activation in NEC arises from a failure in intestinal-specific mechanisms that tamponade TLR signaling (the brakes). In this review, we discussed the human and animal studies that elucidate the developmental mechanisms inhibiting TLR signaling in the postnatal intestine (establishing the brakes). We then evaluate evidence from preclinical models and human studies that point to a defect in the inhibition of TLR signaling underlying NEC. Finally, we provided a framework for the assessment of NEC risk by screening for signatures of TLR signaling and for NEC prevention by TLR-targeted therapy in premature infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.