ReviewNeuropsychologia2023
A revisit of the amygdala theory of autism: Twenty years after.
Review in Neuropsychologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Emotion Reactivity and Regulation in Autistic Adults: A Systematic Review Across RDoC Units of Analysis.Psychophysiology · 2025Pooled it
- The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults.Autism research : official journal of the International Society for Autism Research · 2026Article
- An integrative multi-omics approach identifies microbiome alterations linked to pathological and behavioral features in autism spectrum disorder.Cell reports. Medicine · 2026Article
- Prenatal exposure to extreme heat and autism in children.The Science of the total environment · 2026Article
- Convergence and divergence of genes informed by common and rare variants of autism spectrum disorders in tissue-specific pathways and gene networks.Translational psychiatry · 2026Article
- The Long and Winding Road to Understanding Autism.NeuroSci · 2025Review
- Neuroplasticity-Based Approaches to Sensory Processing Alterations in Autism Spectrum Disorder.International journal of molecular sciences · 2025Review
- Innovative biomarker exploration in ASD: Combining Graph Neural Networks and permutation testing on fMRI data.Neuroimage. Reports · 2025Article
- Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings.Developmental neuroscience · 2025Article
- Evaluating Large Language Models' Ability Using a Psychiatric Screening Tool Based on Metaphor and Sarcasm Scenarios.Journal of Intelligence · 2024Article
- Atypical neural encoding of faces in individuals with autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Face processing in animal models: implications for autism spectrum disorder.Frontiers in neuroscience · 2024Review
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Neural correlates of facial recognition deficits in autism spectrum disorder: a comprehensive review.Frontiers in psychiatry · 2024Review
- The hidden face of Duchenne (Neuro)Muscular Dystrophy. Preliminary evidence of social cognition impairment as a feature of the neuropsychological phenotype of DMD.Frontiers in psychology · 2024Article
- Multimodal investigations of emotional face processing and social trait judgment of faces.Annals of the New York Academy of Sciences · 2024Review
- A uniform human multimodal dataset for emotion perception and judgment.Scientific data · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The human amygdala has long been implicated to play a key role in autism spectrum disorder (ASD). Yet it remains unclear to what extent the amygdala accounts for the social dysfunctions in ASD. Here, we review studies that investigate the relationship between amygdala function and ASD. We focus on studies that employ the same task and stimuli to directly compare people with ASD and patients with focal amygdala lesions, and we also discuss functional data associated with these studies. We show that the amygdala can only account for a limited number of deficits in ASD (primarily face perception tasks but not social attention tasks), a network view is, therefore, more appropriate. We next discuss atypical brain connectivity in ASD, factors that can explain such atypical brain connectivity, and novel tools to analyze brain connectivity. Lastly, we discuss new opportunities from multimodal neuroimaging with data fusion and human single-neuron recordings that can enable us to better understand the neural underpinnings of social dysfunctions in ASD. Together, the influential amygdala theory of autism should be extended with emerging data-driven scientific discoveries such as machine learning-based surrogate models to a broader framework that considers brain connectivity at the global scale.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.