Evidence map›Paper›PMID 36803837›Full record

ArticleTrials2023

Study protocol: short against long antibiotic therapy for infected orthopedic sites - the randomized-controlled SALATIO trials.

Ilker Uçkay, Stephan Wirth, Björn Zörner, Sandro Fucentese, Karl Wieser, Andreas Schweizer, Daniel Müller, Patrick Zingg, Mazda Farshad

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05499481 (Short Against Long Antibiotic Therapy for Infected Orthopedic Sites), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05499481 phase3completednot on this map

Short Against Long Antibiotic Therapy for Infected Orthopedic Sites

TypeinterventionalSponsorBalgrist University HospitalRan2022 to 2025Enrolled495ConditionsOrthopedic Devices Associated With Misadventures, Infection, Surgical Site, Antibiotic Side EffectArmsAntibiotic
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Short or Long Antibiotic Regimens in Orthopedics.The New England journal of medicine · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ilker UçkayDepartment of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, Zurich, Switzerland. ilker.uckay@balgrist.com.ORCID http://orcid.org/0000-0002-5552-0973
Stephan WirthDepartment of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Björn ZörnerSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Sandro FucenteseDepartment of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Karl WieserDepartment of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Andreas SchweizerDepartment of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Daniel MüllerDepartment of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Patrick ZinggDepartment of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Mazda FarshadDepartment of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Funding

Balgrist W956
6 · The paper itself

Abstract

backgroundFew studies address the appropriate duration of post-surgical antibiotic therapy for orthopedic infections; with or without infected residual implants. We perform two similar randomized-clinical trials (RCT) to reduce the antibiotic use and associated adverse events.

methodsTwo unblinded RCTs in adult patients (non-inferiority with a margin of 10%, a power of 80%) with the primary outcomes "remission" and "microbiologically-identical recurrences" after a combined surgical and antibiotic therapy. The main secondary outcome is antibiotic-related adverse events. The RCTs allocate the participants between 3 vs. 6 weeks of post-surgical systemic antibiotic therapy for implant-free infections and between 6 vs. 12 weeks for residual implant-related infections. We need a total of 280 episodes (randomization schemes 1:1) with a minimal follow-up of 12 months. We perform two interim analyses starting approximately after 1 and 2 years. The study approximatively lasts 3 years. DISCUSSION: Both parallel RCTs will enable to prescribe less antibiotics for future orthopedic infections in adult patients.

trial registrationClinicalTrial.gov NCT05499481. Registered on 12 August 2022. PROTOCOL VERSION: 2 (19 May 2022).

Indexed as

Anti-Bacterial AgentsOrthopedic ProceduresSurgical Wound InfectionAdultEquivalence Trials as TopicHumansPostoperative ComplicationsRandomized Controlled Trials as TopicAnti-Bacterial AgentsAdverse eventsAntibiotic durationOrthopedic infectionsOsteomyelitisRemissionSurgical debridement

Identifiers

PMID36803837
PMCPMC9938993

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.