Evidence map›Paper›PMID 36803606›Full record

ArticleBMC infectious diseases2023

Injectable long acting antiretroviral for HIV treatment and prevention: perspectives of potential users.

Laurence Slama, Raphael Porcher, Françoise Linard, Catherine Chakvetadze, Agnès Cros, Séverine Carillon, Lucille Gallardo, Jean-Paul Viard, Jean-Michel Molina

Abstract read
In one paragraph

Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Retention in HIV Care Still Matters: A Longitudinal Multisite Analysis.Journal of acquired immune deficiency syndromes (1999) · 2025
    Article
  10. Observational
  11. Observational
  12. Review
  13. Article
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  16. Journal of the American Chemical Society · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laurence SlamaDepartment of Infectious Diseases, Hôtel Dieu Hospital, APHP, 1 Place du Parvis Notre-Dame, 75004, Paris, France. Laurence.slama@aphp.fr.ORCID http://orcid.org/0000-0002-9871-6036
Raphael PorcherUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), 75004, Paris, France.
Françoise LinardDepartment of Infectious Diseases, Hôtel Dieu Hospital, APHP, 1 Place du Parvis Notre-Dame, 75004, Paris, France.
Catherine ChakvetadzeDepartement of Infectious Diseases, Groupe Hospitalier Sud Île de France, Melun, France.
Agnès CrosDepartment of Infectious Diseases, Hôtel Dieu Hospital, APHP, 1 Place du Parvis Notre-Dame, 75004, Paris, France.
Séverine CarillonCEPED, IRD, Paris Cité University, Paris, France.
Lucille GallardoDepartment of Infectious Diseases, Hôtel Dieu Hospital, APHP, 1 Place du Parvis Notre-Dame, 75004, Paris, France.
Jean-Paul ViardDepartment of Infectious Diseases, Hôtel Dieu Hospital, APHP, 1 Place du Parvis Notre-Dame, 75004, Paris, France.
Jean-Michel MolinaDepartement of Infectious Diseases, Saint Louis and Lariboisière Hospitals, APHP, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of long acting injectable (LAA) antiretroviral drugs may be an alternative option for HIV treatment and prevention. Our study focused on patient perspectives to understand which individuals, among people with HIV (PWH) and pre-exposure prophylaxis (PrEP) users, would constitute the preferential target for such treatments in terms of expectations, tolerability, adherence and quality of life.

methodsThe study consisted in one self-administrated questionnaire. Data collected included lifestyle issues, medical history, perceived benefits and inconveniences of LAA. Groups were compared using Wilcoxon rank tests or Fisher's exact test.

resultsIn 2018, 100 PWH and 100 PrEP users were enrolled. Overall, 74% of PWH and 89% of PrEP users expressed interest for LAA with a significantly higher rate for PrEP users (p = 0.001). No characteristics were associated with acceptance of LAA in both groups in term of demographics, lifestyle or comorbidities.

conclusionPWH and PrEP users expressed a high level of interest in LAA, since a large majority seems to be in favor of this new approach. Further studies should be conducted to better characterize targeted individuals.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisAnti-Retroviral AgentsHomosexuality, MaleHumansInjectionsMaleQuality of LifeAnti-HIV AgentsAnti-Retroviral AgentsHIV preventionHIV treatmentLong-acting cARTPrEPQuantitative study

Identifiers

PMID36803606
PMCPMC9936705

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.