Evidence map›Paper›PMID 36803237›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2023

A national case-control study investigating demographic and environmental factors associated with NMOSD.

Dalia L Rotstein, Christina Wolfson, Robert Carruthers, Mark S Freedman, Sarah A Morrow, Liesly Lee, Jodie M Burton, Rosane Nisenbaum, Andrea Konig, Sandra Magalhaes and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. NMOSD and MOGAD: an evolving disease spectrum.Nature reviews. Neurology · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 1 country.

Dalia L RotsteinDepartment of Medicine, University of Toronto, Toronto, ON, Canada/MS Clinic, St. Michael's Hospital, Toronto, ON, Canada.ORCID 0000-0002-7280-3684
Christina WolfsonDepartments of Epidemiology, Biostatistics and Occupational Health and Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada/Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Robert CarruthersDivision of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-7085-1001
Mark S FreedmanDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada/Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Sarah A MorrowWestern University, London, ON, Canada/London Health Sciences Centre, London, ON, Canada.
Liesly LeeDepartment of Medicine, University of Toronto, Toronto, ON, Canada/Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Jodie M BurtonDepartments of Clinical Neurosciences and Community Health Sciences, University of Calgary, Calgary, AB, Canada.
Rosane NisenbaumSt. Michael's Hospital, Toronto, ON, Canada/Applied Health Research Centre and MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada/Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Andrea KonigSt. Michael's Hospital, Toronto, ON, Canada.
Sandra MagalhaesDepartment of Sociology, University of New Brunswick, Fredericton, NB, Canada.
Ruth Ann MarrieDepartments of Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-1855-5595
St. Michael's Hospital · CAMcGill University Health Centre · CASunnybrook Health Science Centre · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of New Brunswick · CAUniversity of Ottawa · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRisk factors for aquaporin-4 (AQP4+) antibody neuromyelitis optica spectrum disorder (NMOSD) are not well-established.

objectiveTo investigate demographic and environmental factors associated with NMOSD using a validated questionnaire and case-control design.

methodsWe enrolled patients with AQP4 + NMOSD through six Canadian Multiple Sclerosis Clinics. Participants completed the validated Environmental Risk Factors in Multiple Sclerosis Study (EnvIMS) questionnaire. Their responses were compared to those of 956 unaffected controls from the Canadian arm of EnvIMS. We calculated odds ratios (ORs) for the association between each variable and NMOSD using logistic regression and Firth's procedure for rare events.

resultsIn 122 participants (87.7% female) with NMOSD, odds of NMOSD in East Asian and Black participants were ⩾8 times that observed in White participants. Birthplace outside Canada was associated with an increased risk of NMOSD (OR = 5.5, 95% confidence interval (CI) = 3.6-8.3) as were concomitant autoimmune diseases (OR = 2.7, 95% CI = 1.4-5.0). No association was observed with reproductive history or age at menarche.

conclusionIn this case-control study, risk of NMOSD in East Asian and Black versus White individuals was greater than that observed in many previous studies. Despite the preponderance of affected women, we did not observe any association with hormonal factors such as reproductive history or age at menarche.

Indexed as

Multiple SclerosisNeuromyelitis OpticaAquaporin 4AutoantibodiesCanadaCase-Control StudiesDemographyFemaleHumansMaleAquaporin 4Autoantibodiesaquaporin-4epidemiologyNMOSDrisk factors

Identifiers

PMID36803237
PMCPMC10152218
OpenAlexW4321329773

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.