SynthesisBMC anesthesiology2023
Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as prognostic predictors for delirium in critically ill patients: a systematic review and meta-analysis.
Synthesis in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Postoperative delirium in patients with free flap reconstruction after head and neck tumor surgery: influencing factors for severity and onset time, and a prediction model.BMC oral health · 2025Article
- A nomogram and risk stratification for predicting subsyndromal delirium in elderly patients in a post-anaesthesia care unit: A prospective cohort study.International journal of nursing studies advances · 2025Article
- Article
- Direct and indirect associations of stress hyperglycemia with delirium in older adults with community-acquired pneumonia: limited mediation by neutrophil-lymphocyte ratio and procalcitonin.BMC geriatrics · 2025Article
- Postoperative Delirium and Cognitive Dysfunction After Cardiac Surgery: The Role of Inflammation and Clinical Risk Factors.Diagnostics (Basel, Switzerland) · 2025Article
- A nomogram model for prognosis of acute ischemic stroke treated with recombinant tissue-type plasminogen activator.Frontiers in neurology · 2025Article
- Current perspectives on the early identification and management of delirium after acute stroke reperfusion therapy.Frontiers in neurology · 2025Review
- The effect of remimazolam versus conventional anesthesia on postoperative delirium in frail patients: a prospective, controlled cohort study.Frontiers in medicine · 2025Article
- Article
- Association between preoperative neutrophil-lymphocyte ratio, uric acid, and postoperative delirium in elderly patients undergoing degenerative spine surgery.Journal of anesthesia · 2024Observational
- Increased IgA-mediated responses to the gut paracellular pathway and blood-brain barrier proteins predict delirium due to hip fracture in older adults.Frontiers in neurology · 2024Article
- Optimization of the cardiac delirium index by including age, decrease in butyrylcholinesterase actitivity, preoperative HbA1c, and postoperative hemoglobin levels: results of a secondary analysis of a prospective observational study.Frontiers in cardiovascular medicine · 2024Article
- Neutrophil-Lymphocytes Ratio as Potential Early Marker for Alzheimer's Disease.Mediators of inflammation · 2024Article
Corrections and comments
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5 authors.
Funding
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Abstract
introductionIn this systematic review and meta-analysis, we aim to analyze the current literature to evaluate neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) values among critically ill patients who develop delirium as compared to those who do not.
methodsPubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before June 12, 2022. The Newcastle-Ottawa scale was used for quality assessment. Because a significant level of heterogeneity was found, we used the random-effects model to generate pooled effects.
resultsTwenty-four studies including 11,579 critically ill patients, of whom 2439 were diagnosed with delirium, were included in our meta-analysis. Compared with the non-delirious group, the delirious group's NLR levels were significantly higher (WMD = 2.14; CI 95% = 1.48-2.80, p < 0.01). In the subgroup analysis according to the type of critical condition, the NLR levels in patients of delirious group were significantly more than those of non-delirious group in studies on POD, PSD and PCD (WMD = 1.14, CI 95% = 0.38-1.91, p < 0.01, WMD = 1.38, CI 95% = 1.04-1.72, p < 0.001, and WMD = 4.22, CI 95% = 3.47-4.98, p < 0.001, respectively). However, compared with the non-delirious group, the delirious group's PLR levels were not significantly different (WMD = 1.74; CI 95% = -12.39-15.86, p = 0.80).
conclusionOur findings support NLR to be a promising biomarker that can be readily integrated into clinical settings to aid in the prediction and prevention of delirium.
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