ArticleCirculation. Cardiovascular interventions2023
Sustained Mechanical Aspiration Thrombectomy for High Thrombus Burden Coronary Vessel Occlusion: The Multicenter CHEETAH Study.
Article in Circulation. Cardiovascular interventions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06327659 (Efficacy of Using 50 ml Syringe Manual Thrombectomy Catheter in Patients With Heavy Thrombus Burden Undergoing Primary Percutaneous Coronary Intervention), which is not on this map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Using 50 ml Syringe Manual Thrombectomy Catheter in Patients With Heavy Thrombus Burden Undergoing Primary Percutaneous Coronary Intervention
Who cites it
28 citing papers in PubMed, 33 citations in OpenAlex.
- Prognostic Impact of Residual Thrombus After Aspiration Thrombectomy in ST-Elevation Myocardial Infarction.JACC. Asia · 2026Article
- Investigator Gender Influence on Female Enrollment in Multicenter Vascular Trials: A Site-Level Analysis.Cardiovascular and interventional radiology · 2026Article
- Quantitative intramyocardial hemorrhage assessment by conventional T2-weighted imaging improves risk stratification in reperfused STEMI.The international journal of cardiovascular imaging · 2026Article
- Guide-Extension Catheter-Assisted Bail-Out Thrombus Aspiration During PCI for Thrombus-Rich Acute Coronary Syndromes: Contemporary Review and Clinical Case Examples.Journal of clinical medicine · 2026Review
- Beyond Conventional Coronary Aspiration: Advances in Thrombus Management.JACC. Case reports · 2026Article
- A practical approach to the management of percutaneous coronary intervention complications.Frontiers in cardiovascular medicine · 2026Review
- Thrombectomy in acute myocardial infarction: Current evidence, challenges, and emerging technologies.World journal of clinical cases · 2025Review
- Successful Thromboaspiration in STEMI Due to Extensive Coronary Thrombosis of Unclear Cause.JACC. Case reports · 2025Article
- Intracoronary Thrombectomy Using an Off-Label 7-F Power Aspiration System for Inferior STEMI With Large Thrombus Burden.JACC. Case reports · 2025Article
- Sustained mechanical aspiration thrombectomy for acute coronary syndrome with large thrombus burden: The Aspiration, Vasodilators, Imaging, and Stenting (AVIS) protocol.American heart journal plus : cardiology research and practice · 2025Article
- First-in-Human Experience of Targeted Coronary Sonothrombolysis: A Novel Approach for Management of Refractory Coronary Thrombus.JACC. Case reports · 2025Article
- Molecular Mechanisms of Microvascular Obstruction and Dysfunction in Percutaneous Coronary Interventions: From Pathophysiology to Therapeutics-A Comprehensive Review.International journal of molecular sciences · 2025Review
- Identification and Management Strategies for Intracoronary High Thrombus Burden in Patients With STEMI: A Practical Experience and Literature Review.Reviews in cardiovascular medicine · 2025Review
- Safety and Effectiveness of a Peripheral Rheolytic Thrombectomy Catheter in ST-Segment Elevation Myocardial Infarction: A Case Series.Journal of cardiovascular development and disease · 2025Article
- State of the Art of Primary PCI: Present and Future.Journal of clinical medicine · 2025Review
- Late coronary embolisation after transcatheter aortic valve implantation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- Continuous mechanical aspiration thrombectomy for STEMI with high thrombus burden.Cardiology journal · 2025Article
- Approach to large thrombus burden in ST-elevation myocardial infarction.Frontiers in cardiovascular medicine · 2025Review
- Successful pharmaco-mechanical treatment of a subtotally occluded venous bypass graft in a patient presenting with acute coronary syndrome: a case report and review of the current literature on the role of local thrombolysis.Frontiers in cardiovascular medicine · 2025Article
- SCAI Expert Consensus Statement on the Management of Patients With STEMI Referred for Primary PCI.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
Corrections and comments
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Authors and funding
10 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoor myocardial reperfusion due to distal embolization and microvascular obstruction after percutaneous coronary intervention is associated with increased risk of morbidity and mortality. Prior trials have not shown a clear benefit of routine manual aspiration thrombectomy. Sustained mechanical aspiration may mitigate this risk and improve outcomes. The objective of this study is to evaluate sustained mechanical aspiration thrombectomy before percutaneous coronary intervention in high thrombus burden acute coronary syndrome patients.
methodsThis prospective study evaluated the Indigo CAT RX Aspiration System (Penumbra Inc, Alameda CA) for sustained mechanical aspiration thrombectomy before percutaneous coronary intervention at 25 hospitals across the USA. Adults presenting within 12 hours of symptom onset with high thrombus burden and target lesion(s) located in a native coronary artery were eligible. The primary end point was a composite of cardiovascular death, recurrent myocardial infarction, cardiogenic shock, or new or worsening New York Heart Association class IV heart failure within 30 days. Secondary end points included Thrombolysis in Myocardial Infarction thrombus grade, Thrombolysis in Myocardial Infarction flow, myocardial blush grade, stroke, and device-related serious adverse events.
resultsFrom August 2019 through December 2020, a total of 400 patients were enrolled (mean age 60.4 years, 76.25% male). The primary composite end point rate was 3.60% (14/389 [95% CI, 2.0-6.0%]). Rate of stroke within 30 days was 0.77%. Final rates of Thrombolysis in Myocardial Infarction thrombus grade 0, Thrombolysis in Myocardial Infarction flow 3, and myocardial blush grade 3 were 99.50%, 97.50%, and 99.75%, respectively. No device-related serious adverse events occurred.
conclusionsSustained mechanical aspiration before percutaneous coronary intervention in high thrombus burden acute coronary syndrome patients was safe and was associated with high rates of thrombus removal, flow restoration, and normal myocardial perfusion on final angiography.
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