ArticleCirculation. Cardiovascular imaging2023
Coronary Artery Calcium Density and Cardiovascular Events by Volume Level: The MESA.
Article in Circulation. Cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies.Arteriosclerosis, thrombosis, and vascular biology · 2024Pooled it
- Development and Validation of a Coronary Artery Calcium Volume and Density Score.Circulation. Cardiovascular imaging · 2026Article
- Response to "Consideration of Statin Therapy in the Interpretation of Artificial Intelligence-Derived Coronary Artery Calcium Density".Korean journal of radiology · 2026Article
- Longitudinal Changes in Coronary Artery Calcium Distribution and Atherosclerotic Cardiovascular Disease Risk.Journal of the American Heart Association · 2026Article
- Cardiac CT in the Era of Precision Cardiology: From Calcium Scoring to Comprehensive Risk Profiling.Journal of clinical medicine · 2026Review
- Serum asprosin levels as a subclinical atherosclerosis marker in patients with primary hypertension.BMC cardiovascular disorders · 2026Article
- Opportunistic Assessment of Coronary Artery Calcium Volume and Density From Non-Electrocardiogram-Gated Chest CT Using Artificial Intelligence: Prognostic Implications in a Screening Cohort.Korean journal of radiology · 2026Article
- Utility of coronary artery calcium scoring in low-risk patients: The Multi-Ethnic Study of Atherosclerosis (MESA).American journal of preventive cardiology · 2025Article
- Applicability of Effective Atomic Number (Zeff) Image Analysis of Coronary Plaques Measured With Photon- Counting Computed Tomography.Investigative radiology · 2025Article
- Coronary Artery Calcium Distribution and Cardiovascular Risk: MESA.JACC. Cardiovascular imaging · 2025Article
- Beyond the Agatston calcium score: role of calcium density and other calcified plaque markers for cardiovascular disease prediction.Current opinion in cardiology · 2025Review
- Analysis of risk factors for PCI no-reflow in coronary heart disease and construction of related prediction models.American journal of translational research · 2024Article
- Association of apolipoproteins C-I and C-II truncations with coronary heart disease and progression of coronary artery calcium: Multi-Ethnic Study of Atherosclerosis.Atherosclerosis · 2023Article
- Coronary Artery Calcium Scoring in Asymptomatic Patients.HCA healthcare journal of medicine · 2023Review
- First presentation of atherosclerotic cardiovascular disease in previously healthy individuals: The multi-ethnic study of atherosclerosis.Progress in cardiovascular diseasesObservational
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe Agatston coronary artery calcium (CAC) score provides robust cardiovascular disease risk prediction but upweights plaque area by a density factor. Density, however, has been shown to be inversely associated with events. Using CAC volume and density separately improves risk prediction, but it is unclear how to apply this method clinically. We aimed to evaluate the association between CAC density and cardiovascular disease across the spectrum of CAC volume to better understand how to incorporate these metrics into a single score.
methodsWe performed an analysis of MESA (Multi-Ethnic Study of Atherosclerosis) participants with detectable CAC to evaluate the association between CAC density and events by level of CAC volume using multivariable Cox regression models.
resultsIn a cohort of 3316 participants, there was a significant interaction (
conclusionsThe lower risk for CHD associated with higher CAC density varied by level of volume, and volume ≤130 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.