Evidence map›Paper›PMID 36802432›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes: Role of voltage-dependent calcium channels.

Nicholas R Klug, Maria Sancho, Albert L Gonzales, Thomas J Heppner, Rochelle Irene C O'Brien, David Hill-Eubanks, Mark T Nelson

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Review
  3. Pericyte KNature cardiovascular research · 2026
    Article
  4. Article
  5. Skin capillary endothelial cells form a network of spatiotemporally conserved CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. IPbioRxiv : the preprint server for biology · 2026
    Article
  7. A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Systemic nimodipine affects pericyte calcium signaling, resting hemodynamics and neurovascular coupling in healthy mouse brain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  15. Kindlin-2 Deletion in Mural Cells Leads to Vascular Instability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  16. Article
  17. Article
  18. Pericyte Electrical Signalling and Brain Haemodynamics.Basic & clinical pharmacology & toxicology · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Nicholas R KlugDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405.ORCID 0000-0001-7540-0306
Maria SanchoDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405.
Albert L GonzalesDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405.
Thomas J HeppnerDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405.
Rochelle Irene C O'BrienDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405.
David Hill-EubanksDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405.
Mark T NelsonDepartment of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT 05405.
University of Vermont · US

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI ROBERT D HARVEY · 2019 to 2026
$20.3M
Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kathryn H Morelli · 2020 to 2026
$17.4M
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCIDR01NS119971 · NINDS · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2021 to 2025
$2.6M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
Lesions and loss of smooth muscle cells in brain underlies small vessel diseaseRF1NS128963 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JOUTEL, ANNE, NELSON, MARK T · 2022 to 2023
$2.2M
Pericyte Control of Junctional Blood FlowK01HL138215 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI GONZALES, ALBERT LOUIS · 2017 to 2021
$744k
Transitional Segment Hypercontractility in Small Vessel Disease with Intracerebral HemorrhageF32HL152576 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KLUG, NICHOLAS RYAN · 2020 to 2022
$201k
NHLBI NIH HHS F32 HL152576NHLBI NIH HHS K01 HL138215NHLBI NIH HHS R35 HL140027NIGMS NIH HHS P20 GM130459NIGMS NIH HHS P20 GM135007NINDS NIH HHS R01 NS110656NINDS NIH HHS R01 NS119971NINDS NIH HHS RF1 NS128963
6 · The paper itself

Abstract

Arteriolar smooth muscle cells (SMCs) and capillary pericytes dynamically regulate blood flow in the central nervous system in the face of fluctuating perfusion pressures. Pressure-induced depolarization and Ca

Indexed as

CalciumPericytesArteriolesCalcium Channels, L-TypeCalcium, DietaryCentral Nervous SystemCalciumCalcium Channels, L-TypeCalcium, Dietaryautoregulationcerebral blood flowpericytesvascular tone

Identifiers

PMID36802432
PMCPMC9992766
OpenAlexW4321440681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.