ArticleProceedings of the National Academy of Sciences of the United States of America2023
Rotational dive into the water clusters on a simple sugar substrate.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Beyond Hydrogen Bonding: π···π Stacking Directed Self-Assembly of Carboxylic Acid Clusters in the Gas Phase.Angewandte Chemie (International ed. in English) · 2026Article
- Stepwise Hydration Reveals Conformational Switching in Chiral Prolinol.Journal of the American Chemical Society · 2025Article
- Cold-Captured Dynamic Hydration Networks in Oxime-Based Photoswitches: A Theoretical Challenge Uncovered by Rotational Spectroscopy.Angewandte Chemie (International ed. in English) · 2025Article
- Rotational Spectroscopy Pinpoints the Tetrahydrate as the Onset of Water Self-Aggregation in Sevoflurane Hydration.The journal of physical chemistry letters · 2025Article
- Microhydration Dynamics in Molecular Photoswitches: Equilibrium State Reconfiguration in Imine-Based Architectures.Angewandte Chemie (International ed. in English) · 2025Article
- Probing Hydrogen-Bonding Preferences and Methyl Internal Rotation in Sotolon and Sotolon-(HInternational journal of molecular sciences · 2025Article
- Water Cooperativity Impacts Aromatic Interactions in the Aggregation of Benzene with Water.Journal of the American Chemical Society · 2025Article
- Hydrogen Bond Interaction Networks in the Mixed Pentamers of Hydrogen Sulfide and Water.Journal of the American Chemical Society · 2025Article
- Water-Mediated Chiral Resolution of Ag-NHC(Nucleobase) Complexes.Inorganic chemistry · 2025Article
- Determining the Molecular Shape of Progesterone: Insights from Laser Ablation Rotational Spectroscopy.The journal of physical chemistry letters · 2025Article
- Network Models of BACE-1 Inhibitors: Exploring Structural and Biochemical Relationships.International journal of molecular sciences · 2024Article
- Water Arrangements upon Interaction with a Rigid Solute: Multiconfigurational Fenchone-(HJournal of the American Chemical Society · 2024Article
- Molecular Structure of Salicylic Acid and Its Hydrates: A Rotational Spectroscopy Study.International journal of molecular sciences · 2024Article
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
Most biomolecular activity takes place in aqueous environments, and it is strongly influenced by the surrounding water molecules. The hydrogen bond networks that these water molecules form are likewise influenced by their interactions with the solutes, and thus, it is crucial to understand this reciprocal process. Glycoaldehyde (Gly), often considered the smallest sugar, represents a good template to explore the steps of solvation and determine how the organic molecule shapes the structure and hydrogen bond network of the solvating water cluster. Here, we report a broadband rotational spectroscopy study on the stepwise hydration of Gly with up to six water molecules. We reveal the preferred hydrogen bond networks formed when water molecules start to form three-dimensional (3D) topologies around an organic molecule. We observe that water self-aggregation prevails even in these early stages of microsolvation. These hydrogen bond networks manifest themselves through the insertion of the small sugar monomer in the pure water cluster in a way in which the oxygen atom framework and hydrogen bond network resemble those of the smallest three-dimensional pure water clusters. Of particular interest is the identification, in both the pentahydrate and hexahydrate, of the previously observed prismatic pure water heptamer motif. Our results show that some specific hydrogen bond networks are preferred and survive the solvation of a small organic molecule, mimicking those of pure water clusters. A many-body decomposition analysis of the interaction energy is also performed to rationalize the strength of a particular hydrogen bond, and it successfully confirms the experimental findings.
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