Evidence map›Paper›PMID 36802342›Full record

ArticleBiology open2023

Deep learning enabled multi-organ segmentation of mouse embryos.

S M Rolfe, S M Whikehart, A M Maga

Abstract read
In one paragraph

Article in Biology open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Streamlining asymmetry quantification in fetal mouse imaging: A semi-automated pipeline supported by expert guidance.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. ChFluids and barriers of the CNS · 2024
    Article
  11. Opportunities and Challenges in Applying AI to Evolutionary Morphology.Integrative organismal biology (Oxford, England) · 2024
    Review
  12. Integrative organismal biology (Oxford, England) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S M RolfeCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA.ORCID 0000-0001-9514-7774
S M WhikehartCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA.ORCID 0000-0001-7919-9056
A M MagaCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA.ORCID 0000-0002-7921-9018

Funding

Utilization of Advanced Technologies for the Understanding of Human Structural Birth DefectsP01HD104435 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI BEIER, DAVID R. · 2021 to 2025
$8.4M
Inbred Mice Strains: Untapped Resource For Genome-Wide Quantitative Association Study For Craniofacial ShapeR03DE027110 · NIDCR · SEATTLE CHILDREN'S HOSPITAL · PI MAGA, ALI MURAT · 2017 to 2018
$377k
Deep Phenotyping of 3D Data for Candidate Gene Selection from Kids First StudiesR03OD032627 · OD · SEATTLE CHILDREN'S HOSPITAL · PI MAGA, ALI MURAT · 2021 to 2021
$330k
NICHD NIH HHS P01 HD104435NIDCR NIH HHS R03 DE027110NIH HHS R03 OD032627
6 · The paper itself

Abstract

The International Mouse Phenotyping Consortium (IMPC) has generated a large repository of three-dimensional (3D) imaging data from mouse embryos, providing a rich resource for investigating phenotype/genotype interactions. While the data is freely available, the computing resources and human effort required to segment these images for analysis of individual structures can create a significant hurdle for research. In this paper, we present an open source, deep learning-enabled tool, Mouse Embryo Multi-Organ Segmentation (MEMOS), that estimates a segmentation of 50 anatomical structures with a support for manually reviewing, editing, and analyzing the estimated segmentation in a single application. MEMOS is implemented as an extension on the 3D Slicer platform and is designed to be accessible to researchers without coding experience. We validate the performance of MEMOS-generated segmentations through comparison to state-of-the-art atlas-based segmentation and quantification of previously reported anatomical abnormalities in a Cbx4 knockout strain. This article has an associated First Person interview with the first author of the paper.

Indexed as

Deep LearningEmbryo, MammalianAnimalsLigasesMicePolycomb-Group ProteinsLigasesPolycomb-Group ProteinsAutomatedDeep learningEmbryoMicro-CTMouseSegmentation

Identifiers

PMID36802342
PMCPMC9990908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.