ReviewNature reviews. Rheumatology2023
Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis.
Review in Nature reviews. Rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 99 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Investigation of the Effect of Smartphone Usage Levels on Cervical Posture, Tongue Pressure, Balance, and Neck Disability in Individuals With Rheumatoid Arthritis and Ankylosing Spondylitis
Impact of Optimised Protein Intake on Household Work Limitations and Disability in Rheumatoid Arthritis
Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- The prevalence of sarcopenia in spondyloarthritis patients: a meta-analysis.Arthritis research & therapy · 2024Pooled it
- Ultrasound viscoelasticity and attenuation imaging for rheumatoid arthritis-associated muscle quality changes: a clinical transcriptomic study.Clinical rheumatology · 2026Article
- Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.Nature reviews. Drug discovery · 2026Review
- Handgrip strength relative to age- and sex-specific reference values in hospitalised patients with highly active rheumatoid arthritis: a single-centre cross-sectional study.Rheumatology international · 2026Article
- Associations between SARC-F score and FRAX score in patients with rheumatoid arthritis: A cross-sectional study.Clinical rheumatology · 2026Article
- Immunometabolic and translational considerations of dipyridamole in experimental rheumatoid arthritis: comment on the article by Marco-Bonilla et al.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Longitudinal Course of Muscle Status in Patients With Rheumatoid Arthritis.International journal of rheumatic diseases · 2026Article
- Passive, Electromagnetic-Responsive Hydrogel Immunosensor for Exercise Intensity Monitoring Based on Sweat C-Reactive Protein.Advanced healthcare materials · 2026Article
- Sarcopenia, an independent predictor for all-cause mortality in rheumatoid arthritis: Insights from the NHANES database.Medicine · 2026Article
- Prevalence of sarcopenia in patients with rheumatoid arthritis: a cross-sectional study.RMD open · 2026Article
- Revitalizing Muscles: Harnessing Exercise to Modulate Inflammatory Cytokines and Conquer Sarcopenia in Aging.Cell biochemistry and biophysics · 2026Review
- Dissecting Immune Mechanisms Underlying Sarcopenia Using Multi-omics Approaches.Calcified tissue international · 2026Article
- Ultrasound evaluation of muscle quality in rheumatoid arthritis: a reliability study of the Spanish Ultrasound Muscle Assessment in Rheumatoid Arthritis (SpUMAR) score.Arthritis research & therapy · 2026Article
- Male Sex and Obesity are Associated with Sarcopenia in Patients with Rheumatoid Arthritis in the 2008-2011 Korea National Health and Nutrition Examination Survey.Journal of clinical medicine · 2026Article
- Comparison of Lower Extremity Muscle Deterioration in Women with Rheumatoid Arthritis and Healthy Controls: Relationship with Disease Activity, Muscle Strength, and Walking Speed.The Eurasian journal of medicine · 2026Article
- Investigating the utility of sarcopenia associated SARC-F and MSRA questionnaires in identifying falls and self-reported functional impairment in juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2026Article
- Geroscience insights into difficult-to-treat rheumatoid arthritis: the role of unhealthy aging, comorbidity, and therapeutic complexity.GeroScience · 2026Review
- Association of multimorbidity and its patterns with incident possible sarcopenia among middle-aged and older adults: findings from a national prospective cohort study in China.BMC musculoskeletal disorders · 2026Article
- Home-based rehabilitation in interstitial lung disease: picturing the present and drawing the future through a systematic review of the literature.ERJ open research · 2026Review
- Assessing the risk of sarcopenia among community-dwelling older adults in Israel: a national cross-sectional survey.European geriatric medicine · 2026Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia, a disorder that involves the generalized loss of skeletal muscle strength and mass, was formally recognized as a disease by its inclusion in the International Classification of Diseases in 2016. Sarcopenia typically affects older people, but younger individuals with chronic disease are also at risk. The risk of sarcopenia is high (with a prevalence of ≥25%) in individuals with rheumatoid arthritis (RA), and this rheumatoid sarcopenia is associated with increased likelihood of falls, fractures and physical disability, in addition to the burden of joint inflammation and damage. Chronic inflammation mediated by cytokines such as TNF, IL-6 and IFNγ contributes to aberrant muscle homeostasis (for instance, by exacerbating muscle protein breakdown), and results from transcriptomic studies have identified dysfunction of muscle stem cells and metabolism in RA. Progressive resistance exercise is an effective therapy for rheumatoid sarcopenia but it can be challenging or unsuitable for some individuals. The unmet need for anti-sarcopenia pharmacotherapies is great, both for people with RA and for otherwise healthy older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.