Evidence map›Paper›PMID 36801903›Full record

Trial reportScientific reports2023

Transcranial direct current stimulation (tDCS) in depression induces structural plasticity.

Mayank A Jog, Cole Anderson, Antoni Kubicki, Michael Boucher, Amber Leaver, Gerhard Hellemann, Marco Iacoboni, Roger Woods, Katherine Narr

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03556124 nacompletednot on this map

Imaging-guided tDCS Therapy in Major Depression

TypeinterventionalSponsorUniversity of California, Los AngelesRan2018 to 2020Enrolled66ConditionsMajor Depressive DisorderArmsActive - HD tDCS, Sham - HD tDCS, Active - Conventional tDCS, Sham - Conventional tDCS
NCT07217223 narecruitingnot on this mapstarted 2025, after this paper: background citation

Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study

TypeinterventionalSponsorUniversity of California, San DiegoRan2025 to 2027Enrolled10ConditionsTreatment Resistant Depression (TRD), Major Depressive Disorder (MDD)ArmsSpaced Transcranial Direct Current Stimulation (tDCS)
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Mayank A JogDepartment of Neurology, University of California Los Angeles (UCLA), Los Angeles, CA, 90095, USA. mayankjog@gmail.com.
Cole AndersonDiagnostic Imaging Sciences Center, University of Washington, Seattle, WA, 98195, USA.
Antoni KubickiDepartment of Neurology, University of California Los Angeles (UCLA), Los Angeles, CA, 90095, USA.
Michael BoucherSemel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, 90095, USA.
Amber LeaverDepartment of Radiology, Northwestern University, Evanston, IL, 60208, USA.
Gerhard HellemannDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Marco IacoboniDepartment of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, 90095, USA.
Roger WoodsDepartment of Neurology, University of California Los Angeles (UCLA), Los Angeles, CA, 90095, USA.
Katherine NarrDepartment of Neurology, University of California Los Angeles (UCLA), Los Angeles, CA, 90095, USA.
Neurobehavioral Systems · USUniversity of California, Los Angeles · USNorthwestern University · USUniversity of Alabama at Birmingham · USUniversity of Washington · US

Funding

Imaging-guided tDCS therapy in major depressionR33MH110526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NARR, KATHERINE L · 2020 to 2022
$3.2M
Imaging-guided tDCS therapy in major depressionR61MH110526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NARR, KATHERINE L, WANG, DANNY JJ · 2017 to 2018
$2.2M
Optimization of tDCS brain network engagement in depressionK99MH128572 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOG, MAYANK ANANT · 2022 to 2023
$230k
NIMH NIH HHS K99 MH128572NIMH NIH HHS R33 MH110526NIMH NIH HHS R61/R33 MH110526
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique involving administration of well-tolerated electrical current to the brain through scalp electrodes. TDCS may improve symptoms in neuropsychiatric disorders, but mixed results from recent clinical trials underscore the need to demonstrate that tDCS can modulate clinically relevant brain systems over time in patients. Here, we analyzed longitudinal structural MRI data from a randomized, double-blind, parallel-design clinical trial in depression (NCT03556124, N = 59) to investigate whether serial tDCS individually targeted to the left dorso-lateral prefrontal cortex (DLPFC) can induce neurostructural changes. Significant (FWEc p < 0.05) treatment-related gray matter changes were observed with active high-definition (HD) tDCS relative to sham tDCS within the left DLPFC stimulation target. No changes were observed with active conventional tDCS. A follow-up analysis within individual treatment groups revealed significant gray matter increases with active HD-tDCS in brain regions functionally connected with the stimulation target, including the bilateral DLPFC, bilateral posterior cingulate cortex, subgenual anterior cingulate cortex, and the right hippocampus, thalamus and left caudate brain regions. Integrity of blinding was verified, no significant differences in stimulation-related discomfort were observed between treatment groups, and tDCS treatments were not augmented by any other adjunct treatments. Overall, these results demonstrate that serial HD-tDCS leads to neurostructural changes at a predetermined brain target in depression and suggest that such plasticity effects may propagate over brain networks.

Indexed as

Transcranial Direct Current StimulationBrainDepressionDouble-Blind MethodGray MatterHumansPrefrontal Cortex

Identifiers

PMID36801903
PMCPMC9938111
OpenAlexW4321225512

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.