Evidence map›Paper›PMID 36801892›Full record

ArticleSignal transduction and targeted therapy2023

Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization.

Shao-Bin Wang, Yosuke Nagasaka, Dionne Argyle, Ayami Nagasaka, Praveen Yerramothu, Bradley D Gelfand, Jayakrishna Ambati

Abstract readLetter
In one paragraph

Article in Signal transduction and targeted therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shao-Bin Wang *Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA. sw3ta@virginia.edu.ORCID 0000-0002-6699-9406
Yosuke Nagasaka *Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Dionne ArgyleCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ayami NagasakaCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Praveen YerramothuCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Bradley D GelfandCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Jayakrishna AmbatiCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA. ja9qr@virginia.edu.

Funding

Heterogeneity of Mild Cognitive Impairment(MCI)R01AG021028 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 2003 to 2014
$4.6M
Visual system and cognitive biology in normal animals versus in an animal model of Alzheimer's disease with or without diabetes treated with solo or dual inflammasome inhibitorsR01EY031039 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA, GELFAND, BRADLEY DAVID · 2020 to 2024
$3.2M
Defining the role of SINE retrotransposons and inflammasome activation in Alzheimer's diseaseR01AG078892 · NIA · UNIVERSITY OF VIRGINIA · PI Jayakrishna Ambati, Bradley David Gelfand · 2022 to 2026
$3.1M
Non-canonical inflammasome in activation in RPE degenerationR01EY029799 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2019 to 2022
$2.7M
Mechanistic basis of sexual dimorphism in antigen-independent IgG1 angiogenesis regulationR01HL164592 · NHLBI · UNIVERSITY OF VIRGINIA · PI Bradley David Gelfand · 2023 to 2026
$2.7M
Cytosolic SINE retrotransposable element cDNA and mitochondrial DNA in aging retinaR01AG082748 · NIA · UNIVERSITY OF VIRGINIA · PI Jayakrishna Ambati, Bradley David Gelfand · 2023 to 2026
$2.5M
Antigen-independent suppression of ocular angiogenesis via the Fc receptorR01EY028027 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA, GELFAND, BRADLEY DAVID · 2018 to 2022
$2.2M
DICER1 deficiency in aberrant chorioretinal neovascularization - Administrative Supplement OKT RequestR01EY032512 · NEI · UNIVERSITY OF VIRGINIA · PI GELFAND, BRADLEY DAVID · 2021 to 2024
$2.1M
NEI NIH HHS R01 EY028027NEI NIH HHS R01 EY029799NEI NIH HHS R01 EY031039NEI NIH HHS R01 EY032512NHLBI NIH HHS R01 HL164592NIA NIH HHS R01 AG021028NIA NIH HHS R01 AG078892NIA NIH HHS R01 AG082748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Choroidal NeovascularizationVascular Endothelial Growth Factor AAlpha-Ketoglutarate-Dependent Dioxygenase FTOHumansRNA, MessengerVascular Endothelial Growth FactorsAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanRNA, MessengerVascular Endothelial Growth Factor AVascular Endothelial Growth Factors

Identifiers

PMID36801892
PMCPMC9939410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.